2,2,2-trichloro-1-(4-chlorophenyl)ethanone

Base Information

• Chemical Name: 2,2,2-trichloro-1-(4-chlorophenyl)ethanone
• CAS No.: 27704-37-6
• Molecular Formula: C₈H₄Cl₄O
• Molecular Weight: 257.931
• Mol file: 27704-37-6.mol

Synonyms:2,2,2-trichloro-1-(4-chlorophenyl)ethanone

Chemical Property of 2,2,2-trichloro-1-(4-chlorophenyl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,2-trichloro-1-(4-chlorophenyl)ethanone

There total 15 articles about 2,2,2-trichloro-1-(4-chlorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

bromochlorobenzene (106-39-8) + chloral (75-87-6) → 2,2,2-trichloro-1-(4-chlorophenyl)ethanone (27704-37-6)

Guidance literature:

bromochlorobenzene; With magnesium; lithium chloride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

chloral; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

With tert-butylhypochlorite; iodine; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201301170

Reference yield: 94.0%

2,2-dichloro-1-(4-chlorophenyl)ethanone (5157-57-3) → 2,2,2-trichloro-1-(4-chlorophenyl)ethanone (27704-37-6)

Guidance literature:

With manganese triacetate; lithium chloride; In acetic acid; for 3.71667h; Product distribution; Mechanism; Heating; other time and molar ratio;;

DOI:10.1246/bcsj.58.142

Reference yield: 88.0%

(4-chlorophenyl)propiolic acid (3240-10-6) → 2,2,2-trichloro-1-(4-chlorophenyl)ethanone (27704-37-6)

Guidance literature:

With trichloroisocyanuric acid; water; In N,N-dimethyl-formamide; at 5 ℃; for 0.0833333h; Solvent; Temperature; Flow reactor;

DOI:10.1016/j.tetlet.2018.01.067

upstream raw materials:

2,2-dichloro-1-(4-chlorophenyl)ethanone

para-chloroacetophenone

chlorobenzene

trifluoroacetyl chloride

Downstream raw materials:

2,2,2-trichloro-1-(4-chloro-phenyl)-ethanol

Methyl-phosphonic acid 2,2-dichloro-1-(4-chloro-phenyl)-vinyl ester ethyl ester

N-benzoylpiperidine

4-(trichloromethyl)-4-(4-chlorophenyl)-2-oxetanone

Refernces

• 1、 Gulizhabaier,Rexit. "Synthesis of Trihalomethyl Ketones from Trihalomethyl Carbinols (Hal = Cl, Br) Using 2-Iodoxybenzoic Acid". . p. 809 - 815. Retrieved 2021/06/12.
• 2、 Jayaraman, Aravindan,Cho, Eunjeong,Irudayanathan, Francis Mariaraj,Kim, Jimin,Lee, Sunwoo. "Metal-Free Decarboxylative Trichlorination of Alkynyl Carboxylic Acids: Synthesis of Trichloromethyl Ketones". . p. 130 - 141. Retrieved 2017/12/26.