4-BENZYLPHENYLGLYCIDYLETHER

Base Information

• Chemical Name: 4-BENZYLPHENYLGLYCIDYLETHER
• CAS No.: 5296-38-8
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.302
• Mol file: 5296-38-8.mol

Synonyms:Oxirane,[[4-(phenylmethyl)phenoxy]methyl]- (9CI); Propane, 1,2-epoxy-3-[(a-phenyl-p-tolyl)oxy]- (7CI,8CI);4-Benzylphenyl glycidyl ether; p-Benzylphenyl glycidyl ether

Chemical Property of 4-BENZYLPHENYLGLYCIDYLETHER

Chemical Property:

• Vapor Pressure: 1.95E-05mmHg at 25°C
• Boiling Point: 373.2°Cat760mmHg
• Flash Point: 151.4°C
• PSA: 21.76000
• Density: 1.127g/cm³
• LogP: 3.05500

Purity/Quality:

99%min ^*data from raw suppliers

4-BENZYLPHENYLGLYCIDYL ETHER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BENZYLPHENYLGLYCIDYLETHER

There total 3 articles about 4-BENZYLPHENYLGLYCIDYLETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

p-benzylphenol (101-53-1) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 2-((4-benzylphenoxy)methyl)oxirane (5296-38-8)

Guidance literature:

With tetrapropylammonium iodide; potassium hydroxide; at 20 ℃;

DOI:10.1016/j.bmcl.2012.05.072

Reference yield:

p-benzylphenol (101-53-1) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 2-((4-benzylphenoxy)methyl)oxirane (5296-38-8) + 3--2-hydroxy-propylchlorid (19408-97-0)

Guidance literature:

With potassium hydroxide; at 20 ℃; Title compound not separated from byproducts;

Reference yield:

p-benzylphenol (101-53-1) + 1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → 2-((4-benzylphenoxy)methyl)oxirane (5296-38-8) + C16H17BrO2

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In acetonitrile; for 10h; Reflux;

DOI:10.1002/hlca.201100324

upstream raw materials:

p-benzylphenol

epichlorohydrin

1,2-Epoxy-3-bromopropane

Refernces

• 1、 Kumar, Arun Babu,Anderson, Jordan Micheal,Melendez, Anthony Lester,Manetsch, Roman. "Synthesis and structure-activity relationship studies of 1,3-disubstituted 2-propanols as BACE-1 inhibitors". supporting information; experimental part. p. 4740 - 4744. Retrieved 2012/08/07.