Nomegestrol

Base Information

• Chemical Name: Nomegestrol
• CAS No.: 58691-88-6
• Molecular Formula: C₂₁H₂₈O₃
• Molecular Weight: 328.452
• UNII: 10F89177CO
• DSSTox Substance ID: DTXSID80866702
• Nikkaji Number: J126.259I
• Wikipedia: Nomegestrol
• Wikidata: Q1722024
• NCI Thesaurus Code: C87243
• Metabolomics Workbench ID: 152759
• ChEMBL ID: CHEMBL2105722
• Mol file: 58691-88-6.mol

Synonyms:Lutenyl;nomegestrol

Chemical Property of Nomegestrol

Chemical Property:

• Vapor Pressure: 3.32E-12mmHg at 25°C
• Melting Point: 204-205 °C
• Refractive Index: 1.573
• Boiling Point: 502.6 °C at 760 mmHg
• PKA: 12.99±0.60(Predicted)
• Flash Point: 271.8 °C
• PSA: 54.37000
• Density: 1.17g/cm³
• LogP: 3.61440
• Storage Temp.: 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 328.20384475
• Heavy Atom Count: 24
• Complexity: 673

Purity/Quality:

99% ^*data from raw suppliers

Nomegestrol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2C(CCC3(C2CCC3(C(=O)C)O)C)C4C1=CC(=O)CC4
• Isomeric SMILES: CC1=C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)O)C)[C@@H]4C1=CC(=O)CC4
• Recent EU Clinical Trials: A phase I, single center, open-label parallel group trial to compare the pharmacokinetics of NOMAC between healthy female adolescents (aged 14-17 years) and healthy female adults (aged 18-50 years) after single dose administration of NOMAC-E2 tablets
• Description: Nomegestrol acetate is the 19-nor derivative of megestrol acetate, useful in the treatment of gynecological conditions associated with luteal deficiency. Nomegestrol is a derivative of 19-norprogesterone. It increases nuclear levels of the progesterone receptor in rat uterus when administered at a dose of 1 mg/animal.
• Uses: A progestogen, derivatives of which are used in contraceptives and hormone therapies. Progetin used in implantable hormone replacement therapies.

Technology Process of Nomegestrol

There total 1 articles about Nomegestrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (10R,13S,17R)-17-Acetyl-17-hydroxy-6,13-dimethyl-1,2,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one (5514-85-2,58691-88-6)

Guidance literature:

Pregnadien-4,6 (Formel 7a), Kaliummethylat;