Technology Process of N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-methoxyphenyl)-β-alanine
There total 5 articles about N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-methoxyphenyl)-β-alanine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-[N-(t-butoxycarbonyl)-isoindoline-5-yl]amino-4-oxobutyric acid;
With
triethylamine; isobutyl chloroformate;
In
N,N-dimethyl-formamide;
at -10 ℃;
for 0.5h;
sodium; 3-amino-3-(4-methoxy-phenyl)-propionate;
In
N,N-dimethyl-formamide;
at -10 - 20 ℃;
for 2.5h;
DOI:10.1134/S1070428006080124
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 94 percent / Na2CO3 / CHCl3 / 5 h / 20 °C
2.1: hydrazine hydrate / Pd/C / dioxane / 60 °C
3.1: CHCl3 / 0.5 h / Heating
4.1: triethylamine; isobutyl chloroformate / dimethylformamide / 0.5 h / -10 °C
4.2: 73 percent / dimethylformamide / 2.5 h / -10 - 20 °C
With
sodium carbonate; hydrazine hydrate; triethylamine; isobutyl chloroformate;
palladium on activated charcoal;
In
1,4-dioxane; chloroform; N,N-dimethyl-formamide;
DOI:10.1134/S1070428006080124
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 94 percent / Na2CO3 / CHCl3 / 5 h / 20 °C
2.1: hydrazine hydrate / Pd/C / dioxane / 60 °C
3.1: CHCl3 / 0.5 h / Heating
4.1: triethylamine; isobutyl chloroformate / dimethylformamide / 0.5 h / -10 °C
4.2: 73 percent / dimethylformamide / 2.5 h / -10 - 20 °C
With
sodium carbonate; hydrazine hydrate; triethylamine; isobutyl chloroformate;
palladium on activated charcoal;
In
1,4-dioxane; chloroform; N,N-dimethyl-formamide;
DOI:10.1134/S1070428006080124