Technology Process of 2-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-(5-fluoro-pyridin-2-ylmethyl)cyclopentane-1,3-dione
There total 8 articles about 2-[3-(4-chloro-phenyl)-5-methyl-pyrazol-1-yl]-4-(5-fluoro-pyridin-2-ylmethyl)cyclopentane-1,3-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
5%-palladium/activated carbon;
In
methanol;
for 6h;
under 1125.11 Torr;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C
1.2: 0.5 h / 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 200 °C / microwave irradiation
3.1: potassium carbonate / acetone / 3 h / 60 °C
4.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.5 h / -78 °C / Inert atmosphere
4.2: 1 h / -78 - 20 °C
5.1: hydrogenchloride; water / acetone / 1 h / 120 °C / microwave irradiation
6.1: hydrogen / 5%-palladium/activated carbon / methanol / 6 h / 1125.11 Torr
With
hydrogenchloride; water; hydrogen; sodium hydride; potassium carbonate; lithium diisopropyl amide;
5%-palladium/activated carbon;
In
tetrahydrofuran; methanol; n-heptane; ethylbenzene; N,N-dimethyl-formamide; acetone; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 200 °C / microwave irradiation
2.1: potassium carbonate / acetone / 3 h / 60 °C
3.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.5 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 - 20 °C
4.1: hydrogenchloride; water / acetone / 1 h / 120 °C / microwave irradiation
5.1: hydrogen / 5%-palladium/activated carbon / methanol / 6 h / 1125.11 Torr
With
hydrogenchloride; water; hydrogen; potassium carbonate; lithium diisopropyl amide;
5%-palladium/activated carbon;
In
tetrahydrofuran; methanol; n-heptane; ethylbenzene; N,N-dimethyl-formamide; acetone;