4H-Pyrido[1,2-a]pyrimidin-4-one, 9-methyl-3-(2H-tetrazol-5-yl)-, potassium salt (1:1)

Base Information

• Chemical Name: 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-methyl-3-(2H-tetrazol-5-yl)-, potassium salt (1:1)
• CAS No.: 100299-08-9
• Molecular Formula: C₁₀H₇N₆O*K
• Molecular Weight: 266.303
• Mol file: 100299-08-9.mol

Synonyms:4H-Pyrido[1,2-a]pyrimidin-4-one, 9-methyl-3-(2H-tetrazol-5-yl)-, potassium salt (1:1);SCHEMBL98855;AKOS015900181;A800089;potassium 9-methyl-3-(2H-tetrazol-5-yl)pyrido[1,2-a]pyrimidin-4-one;Pemirolast potassium

Chemical Property of 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-methyl-3-(2H-tetrazol-5-yl)-, potassium salt (1:1)

Chemical Property:

• Appearance/Colour: crystalline solid
• Vapor Pressure: 1.85E-08mmHg at 25°C
• Melting Point: 310-311 °C (dec.)
• Boiling Point: 454.8 °C at 760 mmHg
• Flash Point: 228.9 °C
• PSA: 77.97000
• LogP: -0.03120
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: H2O: ≥18mg/mL
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 267.03966538
• Heavy Atom Count: 18
• Complexity: 489

Purity/Quality:

99% ^*data from raw suppliers

Pemirolast Potassium Salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CN2C1=NC=C(C2=O)C3=NNN=N3.[K]
• Description: Pemirolast potassium is a new potent antiallergic mast cell stabilizer with a similar mechanism to sodium cromoglycate. Its main indication is bronchial asthma. Another indication under investigation is as a gastroprotective agent.
• Uses: Inhibitor of chemical mediator release from tissue mast cells. Antiallergic Pemirolast potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent Inhibitor of chemical mediator release from tissue mast cells. Antiallergic.
• Therapeutic Function: Antiallergic, Antiulcer

Technology Process of 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-methyl-3-(2H-tetrazol-5-yl)-, potassium salt (1:1)

There total 3 articles about 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-methyl-3-(2H-tetrazol-5-yl)-, potassium salt (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

pemirolast (69372-19-6) → Pemirolast potassium (100299-08-9)

Guidance literature:

With potassium hydroxide; In isopropyl alcohol; at 50 ℃; for 1h;

DOI:10.3987/COM-97-8086

Reference yield: 95.0%

(Z)-3-(3-Methyl-pyridin-2-ylamino)-2-(1H-tetrazol-5-yl)-acrylic acid ethyl ester → Pemirolast potassium (100299-08-9)

Guidance literature:

With potassium hydroxide; In isopropyl alcohol; for 2h; Heating;

DOI:10.3987/COM-97-8086

Reference yield:

3-methylpyridin-2-ylamine (1603-40-3) → Pemirolast potassium (100299-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / NaN₃ / acetic acid / 2 h / 90 °C

2: 95 percent / 2N KOH / propan-2-ol / 2 h / Heating

With potassium hydroxide; sodium azide; In acetic acid; isopropyl alcohol;

DOI:10.3987/COM-97-8086

upstream raw materials:

pemirolast

3-methylpyridin-2-ylamine

Refernces

• 1、 -. "Process for the preparation of high purity pemirolast". . . Retrieved 2008/06/13.