Prednisolut

Base Information

• Chemical Name: Prednisolut
• CAS No.: 2920-86-7
• Molecular Formula: C25H32O8
• Molecular Weight: 460.524
• Hs Code.: 2937290000
• European Community (EC) Number: 220-861-8
• DSSTox Substance ID: DTXSID80859674
• Mol file: 2920-86-7.mol

Synonyms:Prednisolut;4-[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy]-4-oxobutanoic acid;Prednisolonbisuccinat [German];C25H32O8;Prednisolonbisuccinat;EINECS 220-861-8;Prednisolone 21-(hydrogen succinate);4-[(11,17-Dihydroxy-3,20-dioxopregna-1,4-dien-21-yl)oxy]-4-oxobutanoic acid;NCGC00183124-01;SCHEMBL13026153;DTXSID80859674;(11beta)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxypregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-(hydrogen succinate);Pregna-1,4-diene-3,20-dione, 11.beta.,17,21-trihydroxy-, 21-(hydrogen succinate);Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11-beta)-;Pregna-1,4-diene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11beta)-;BCP34113;LS-118503;FT-0634552;F85234;Prednisolone Impurity 4;Prednisolone 21-hemisuccinate

Chemical Property of Prednisolut

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 206°C
• Refractive Index: 1.6
• Boiling Point: 689.821 °C at 760 mmHg
• PKA: 4.29±0.17(Predicted)
• Flash Point: 233.528 °C
• PSA: 138.20000
• Density: 1.359 g/cm³
• LogP: 1.97330
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 460.20971797
• Heavy Atom Count: 33
• Complexity: 950

Purity/Quality:

99% ^*data from raw suppliers

Prednisolone hemisuccinate ^*data from reagent suppliers

Safty Information:

• Statements: 61-40
• Safety Statements: 53-22-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC12CC(C3C(C1CCC2(C(=O)COC(=O)CCC(=O)O)O)CCC4=CC(=O)C=CC34C)O
• Uses: Prednisolone hemisuccinate, is a metabolite of Prednisolone (P703740), which is a synthetic glucocorticoid, a derivative of cortisol, and can be used to treat a variety of inflammatory and auto-immune conditions. It is also the active metabolite of the drug prednisone.

Technology Process of Prednisolut

There total 6 articles about Prednisolut which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

succinic acid anhydride (108-30-5) + prednisolon (50-24-8,8056-11-9) → prednisolone hemisuccinate (2920-86-7)

Guidance literature:

With pyridine; at 20 ℃; for 24h;

DOI:10.1016/j.bmc.2004.06.012

Reference yield:

(5-nitrothien-2-yl)methyl prednisolone-21-yl butanedioate (570370-45-5) → (5-nitrothiophen-2-yl)methanol (20898-85-5) + prednisolone hemisuccinate (2920-86-7)

Guidance literature:

With tin(ll) chloride; In methanol; at 40 ℃; Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(03)00481-2

Reference yield:

→ prednisolone hemisuccinate (2920-86-7)

Guidance literature:

upstream raw materials:

(5-nitrothien-2-yl)methyl prednisolone-21-yl butanedioate

succinic acid anhydride

prednisolon

Downstream raw materials:

prednisolone-21-O-β-carbonylpropionic acid p-nitrophenolic ester

prednisolon

succinic acid

Refernces

• 1、 Lin, Yan,Sun, Xun,Gong, Tao,Zhang, Zhi Rong. "Prednisolone succinate-glucosamine conjugate: Synthesis, characterization and in vitro cellular uptake by kidney cell lines". scheme or table. p. 25 - 28. Retrieved 2012/04/04.
• 2、 Wang, Chao,Zhao, Ming,Qiu, Xuecai,Peng, Shiqi. "The synthesis and immunosuppressive activities of steroid-urotoxin linkers". . p. 4403 - 4421. Retrieved 2007/10/03.