1-(3,4-dimethoxyphenyl)-2-(3,5-dimethoxyphenyl)ethanone

Base Information

• Chemical Name: 1-(3,4-dimethoxyphenyl)-2-(3,5-dimethoxyphenyl)ethanone
• CAS No.: 120078-23-1
• Molecular Formula: C₁₈H₂₀O₅
• Molecular Weight: 316.354
• Mol file: 120078-23-1.mol

Synonyms:1-(3,4-dimethoxyphenyl)-2-(3,5-dimethoxyphenyl)ethanone

Chemical Property of 1-(3,4-dimethoxyphenyl)-2-(3,5-dimethoxyphenyl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,4-dimethoxyphenyl)-2-(3,5-dimethoxyphenyl)ethanone

There total 7 articles about 1-(3,4-dimethoxyphenyl)-2-(3,5-dimethoxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-dimethoxybenzene (91-16-7) + 2-(3,5-dimethoxyphenyl)acetyl chloride (15601-07-7) → 1-(3,4-dimethoxyphenyl)-2-(3,5-dimethoxyphenyl)ethanone (120078-23-1)

Guidance literature:

With aluminum (III) chloride; at 0 - 20 ℃;

DOI:10.3184/174751915X14258938697567

Reference yield:

3,5-dimethoxybenzaldehdye (7311-34-4) → 1-(3,4-dimethoxyphenyl)-2-(3,5-dimethoxyphenyl)ethanone (120078-23-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / HAc/NaAc

2: 1.) NaOH; 2.) H₂O₂

3: 1.) SOCl₂; 2.) AlCl₃

With sodium hydroxide; aluminium trichloride; thionyl chloride; dihydrogen peroxide; sodium acetate; acetic acid;

Reference yield:

trans-1-(3,5-Dimethoxyphenyl)-2-nitroethylene (86255-43-8) → 1-(3,4-dimethoxyphenyl)-2-(3,5-dimethoxyphenyl)ethanone (120078-23-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tetrahydroborate / ethyl acetate; ethanol / 2 h / 20 °C

2: acetic acid; sodium nitrite / dimethyl sulfoxide / 2 h / 35 °C

3: thionyl chloride / dichloromethane / 1 h / Reflux

4: aluminum (III) chloride / 0 - 20 °C

With aluminum (III) chloride; sodium tetrahydroborate; thionyl chloride; acetic acid; sodium nitrite; In ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; 2: |Nef Reaction / 4: |Friedel-Crafts Acylation;

DOI:10.3184/174751915X14258938697567

upstream raw materials:

1,2-dimethoxybenzene

(3,5-dimethoxyphenyl)acetic acid

3,5-dimethoxybenzaldehdye

Azalactone of α-benzoylamino-β-(3,5-dimethoxyphenyl)acrylic acid

Downstream raw materials:

1-(3,4-dimethoxyphenyl)-2-(3',5'-dimethoxyphenyl)ethan-1-ol

Refernces

• 1、 Mannila, Erkki,Talvitie, Antti. "Combretastatin Analogs via Hydration of Stilbene Derivatives". . p. 1037 - 1040. Retrieved 2007/10/02.