Thiazole, 4,5-dihydro-2-phenyl-

Base Information

• Chemical Name: Thiazole, 4,5-dihydro-2-phenyl-
• CAS No.: 2722-34-1
• Molecular Formula: C9H9 N S
• Molecular Weight: 163.243
• DSSTox Substance ID: DTXSID20181688
• Nikkaji Number: J425.756A
• Wikidata: Q83052313
• ChEMBL ID: CHEMBL3323441
• Mol file: 2722-34-1.mol

Synonyms:4,5-Dihydro-2-phenylthiazole;Thiazole, 4,5-dihydro-2-phenyl-;BRN 0119252;2722-34-1;Phenyl-2 delta-2 thiazoline [French];Phenyl-2 delta-2 thiazoline;phenylthiazoline;2-Phenyl-2-thiazoline;SCHEMBL1147751;2-phenyl-4,5-dihydro-thiazole;CHEMBL3323441;DTXSID20181688;2-phenyl-4,5-dihydro-1,3-thiazol;AKOS006372932;LS-150965

Chemical Property of Thiazole, 4,5-dihydro-2-phenyl-

Chemical Property:

• Vapor Pressure: 0.00648mmHg at 25°C
• Boiling Point: 280.3°C at 760 mmHg
• Flash Point: 123.3°C
• PSA: 37.66000
• Density: 1.17g/cm³
• LogP: 1.61560
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 163.04557046
• Heavy Atom Count: 11
• Complexity: 159

Purity/Quality:

2-PHENYL-4,5-DIHYDRO-1,3-THIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CSC(=N1)C2=CC=CC=C2

Technology Process of Thiazole, 4,5-dihydro-2-phenyl-

There total 49 articles about Thiazole, 4,5-dihydro-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-mercaptoethylamine hydrochloride (156-57-0) + benzonitrile (100-47-0) → 2-phenylthiazoline (2722-34-1)

Guidance literature:

With sodium hydroxide; In neat (no solvent); at 80 ℃; for 2h; Reagent/catalyst; Time;

DOI:10.1039/c5gc00286a

Reference yield: 98.0%

benzonitrile (100-47-0) + Cysteamine (60-23-1) → 2-phenylthiazoline (2722-34-1)

Guidance literature:

With tribromomelamine; at 100 ℃; for 0.05h; Neat (no solvent);

DOI:10.1155/2012/972109

Reference yield: 95.0%

N-[2-(triphenylmethylsulfanyl)ethyl]benzamide (1137241-53-2) → 2-phenylthiazoline (2722-34-1)

Guidance literature:

With 1,1,3,3-tetraphenyl-2-oxa-1,3-phospholanium bis(trifluoromethanesulfonate); In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/b818310d

upstream raw materials:

1,4-dithiane-2,5-diol

benzaldehyde

N,N'-(2,2'-disulfanediylbis(ethane-2,1-diyl))dibenzamide

N-(2-benzylsulfanyl-ethyl)-benzamide

Downstream raw materials:

2-phenyl-2-imidazoline

2-phenyl-1,3-oxazoline

2-phenyl-1,4,5,6-tetrahydropyrimidine

4,5-dihydro-4,4-dimethyl-2-phenoxazole

Refernces

• 1、 Wei, Wenxin,Li, Run,Huber, Niklas,Kizilsavas, G?nül,Ferguson, Calum T. J.,Landfester, Katharina,Zhang, Kai A. I.. "Visible Light-Promoted Aryl Azoline Formation over Mesoporous Organosilica as Heterogeneous Photocatalyst". . p. 3410 - 3413. Retrieved 2021/05/29.
• 2、 Bisceglia, Juan A.,Kilimciler, Natalia B.,Mancinelli, Michele,Mollo, María C.,Orelli, Liliana R.. "Microwave-Assisted Synthesis of 2-Substituted 2-Thiazolines and 5,6-Dihydro-4 H -1,3-thiazines". . p. 1666 - 1679. Retrieved 2020/06/01.