Technology Process of 3-(5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophen-2-yl)-2-cyanoacrylic acid
There total 4 articles about 3-(5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophen-2-yl)-2-cyanoacrylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
piperidine;
In
acetonitrile;
for 24h;
Reflux;
Inert atmosphere;
DOI:10.1021/ol203298r
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.25 h / -78 °C / Inert atmosphere
1.2: 1 h / -78 °C / Inert atmosphere
2.1: piperidine / acetonitrile / 24 h / Reflux; Inert atmosphere
With
piperidine; n-butyllithium;
In
tetrahydrofuran; hexanes; acetonitrile;
1.2: Wittig-Horner reaction / 2.1: Knoevenagel condensation;
DOI:10.1021/ol203298r
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) / diethyl ether / 20 h / 0 °C / Inert atmosphere; Reflux
2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / hexane / 0.5 h / Reflux; Inert atmosphere
2.2: -40 - 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.25 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 °C / Inert atmosphere
4.1: piperidine / acetonitrile / 24 h / Reflux; Inert atmosphere
With
piperidine; n-butyllithium; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); N,N,N,N,-tetramethylethylenediamine;
In
tetrahydrofuran; hexanes; diethyl ether; hexane; acetonitrile;
3.2: Wittig-Horner reaction / 4.1: Knoevenagel condensation;
DOI:10.1021/ol203298r