Technology Process of 3-(5-(3-isopropyl-1,2,4-oxadiazol-5-ylamino)-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one
There total 15 articles about 3-(5-(3-isopropyl-1,2,4-oxadiazol-5-ylamino)-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C22H25N5O2;
With
hydrogenchloride; sodium hypochlorite;
In
methanol; water;
at 20 ℃;
With
sodium carbonate;
In
methanol; water;
at 65 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: water; potassium hydroxide / methanol / 14 h / Reflux
2.1: hydrogenchloride / 1,4-dioxane / 14 h / Reflux
2.2: pH > 12
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C
5.1: tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C
6.2: 4 h / 20 °C
7.1: hydrogenchloride; sodium hypochlorite / methanol; water / 20 °C
7.2: 12 h / 65 °C
With
hydrogenchloride; sodium hypochlorite; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
tris-(dibenzylideneacetone)dipalladium(0); palladium 10% on activated carbon; triphenylphosphine;
In
1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C
2.1: tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C
3.2: 4 h / 20 °C
4.1: hydrogenchloride; sodium hypochlorite / methanol; water / 20 °C
4.2: 12 h / 65 °C
With
hydrogenchloride; sodium hypochlorite; potassium carbonate; N-ethyl-N,N-diisopropylamine;
tris-(dibenzylideneacetone)dipalladium(0); triphenylphosphine;
In
1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;