1-bromo-2-fluoro-4-pent-1-ynylbenzene

Base Information

• Chemical Name: 1-bromo-2-fluoro-4-pent-1-ynylbenzene
• CAS No.: 136434-78-1
• Molecular Formula: C₁₁H₁₀BrF
• Molecular Weight: 241.103
• Mol file: 136434-78-1.mol

Synonyms:1-bromo-2-fluoro-4-pent-1-ynylbenzene

Chemical Property of 1-bromo-2-fluoro-4-pent-1-ynylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-bromo-2-fluoro-4-pent-1-ynylbenzene

There total 6 articles about 1-bromo-2-fluoro-4-pent-1-ynylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetrakis(triphenylphosphine) palladium(0) (14221-01-3) + 1-Pentyne (627-19-0) → 1-bromo-2-fluoro-4-pent-1-ynylbenzene (136434-78-1)

Guidance literature:

With n-butyllithium; Zinc chloride; In tetrahydrofuran; hexane;

Reference yield:

meta-fluoroaniline (372-19-0) → 1-bromo-2-fluoro-4-pent-1-ynylbenzene (136434-78-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 70 percent / acetic acid / 0.33 h / Heating

2: 100 percent / NBS / CH₂Cl₂ / a) reflux, 5 h, b) room temp., 16 h

3: 99 percent / 36percent HCl / ethanol / 2 h / Heating

4: 1) 36percent HCl, NaNO₂, 2) KI / 1) H₂O, 0 deg C, 20 min, 2) H₂O, cyclohexane, room temp., 16 h

With hydrogenchloride; N-Bromosuccinimide; potassium iodide; sodium nitrite; In ethanol; dichloromethane; acetic acid;

Reference yield:

N-(3-fluorophenyl)acetamide (351-28-0) → 1-bromo-2-fluoro-4-pent-1-ynylbenzene (136434-78-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / NBS / CH₂Cl₂ / a) reflux, 5 h, b) room temp., 16 h

2: 99 percent / 36percent HCl / ethanol / 2 h / Heating

3: 1) 36percent HCl, NaNO₂, 2) KI / 1) H₂O, 0 deg C, 20 min, 2) H₂O, cyclohexane, room temp., 16 h

With hydrogenchloride; N-Bromosuccinimide; potassium iodide; sodium nitrite; In ethanol; dichloromethane;

upstream raw materials:

1-Pentyne

4-bromo-3-fluoroiodobenzene

meta-fluoroaniline

N-(3-fluorophenyl)acetamide

Downstream raw materials:

1-Bromo-2-fluoro-4-pentylbenzene

Refernces

• 1、 Gray, G. W.,Hird, M.,Toyne, K. J.. "The Synthesis of Several Lateral Difluoro-substituted 4,4''-Dialkyl- and 4,4''-Alkoxyalkyl-Terphenyls and a Rationalisation of the Effect of Such Substitution on Mesophase Type and Transition Temperatures". . p. 43 - 64. Retrieved 2007/10/02.