Piromidic acid

Base Information

• Chemical Name: Piromidic acid
• CAS No.: 19562-30-2
• Molecular Formula: C14H16 N4 O3
• Molecular Weight: 288.306
• European Community (EC) Number: 243-161-4
• NSC Number: 758179,291120
• UNII: 3I12WH4EWF
• DSSTox Substance ID: DTXSID4045424
• Nikkaji Number: J3.146A
• Wikipedia: Piromidic_acid
• Wikidata: Q745206
• NCI Thesaurus Code: C66433
• Metabolomics Workbench ID: 154526
• ChEMBL ID: CHEMBL311350
• Mol file: 19562-30-2.mol

Synonyms:Acid, Piromidic;Piromidic Acid

Chemical Property of Piromidic acid

Chemical Property:

• Vapor Pressure: 5.58E-11mmHg at 25°C
• Melting Point: 314-316°
• Refractive Index: 1.6000 (estimate)
• Boiling Point: 504°Cat760mmHg
• PKA: 4.14±0.20(Predicted)
• Flash Point: 258.6°C
• PSA: 88.32000
• Density: 1.4g/cm³
• LogP: 1.17480
• Storage Temp.: 0-6°C
• Solubility.: Chloroform (Slightly, Heated, Sonicated), Ethanol (Slightly, Heated), Methanol (
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 288.12224039
• Heavy Atom Count: 21
• Complexity: 473

Purity/Quality:

99% ^*data from raw suppliers

PiromidicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCCC3)C(=O)O
• Description: Piromidic acid is a quinolone antibiotic that is active against Gram-positive and Gram-negative bacteria including S. aureus and E. coli (MICs = 10 and 1 μg/ml, respectively). It inhibits growth of nalidixic acid-sensitive strains of E. coli in an in vitro model of bacterial cystitis when used at concentrations of 10 and 50 mg/L. Piromidic acid also has antimalarial properties and is active against chloroquine-sensitive and -resistant strains of P. falciparum in vitro (IC50s = 41.4 and 14.4 μg/ml, respectively) as well as against hepatic stages of P. yoelii yoelii (IC50 = 21.6 μg/ml).
• Uses: Antibacterial;Topoisomerase II inhibitor Piromidic acid is a quinolone antibacterial.
• Therapeutic Function: Antibacterial (urinary)

Technology Process of Piromidic acid

There total 1 articles about Piromidic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ piromidic acid (19562-30-2)

Guidance literature:

Refernces