4-Ethoxy-3-methoxyphenethylamine

Base Information

• Chemical Name: 4-Ethoxy-3-methoxyphenethylamine
• CAS No.: 36377-59-0
• Molecular Formula: C11H17NO2
• Molecular Weight: 195.261
• Hs Code.: 2922299090
• European Community (EC) Number: 674-198-8
• UNII: P4MS942R6J
• DSSTox Substance ID: DTXSID40189904
• Wikipedia: 3-Methoxy-4-ethoxyphenethylamine
• Wikidata: Q4634158
• Mol file: 36377-59-0.mol

Synonyms:4-Ethoxy-3-methoxyphenethylamine;36377-59-0;2-(4-Ethoxy-3-methoxyphenyl)ethanamine;Benzeneethanamine,4-ethoxy-3-methoxy-;P4MS942R6J;2-(4-ethoxy-3-methoxyphenyl)ethan-1-amine;3-Methoxy-4-ethoxyphenethylamine;4-Ethoxy-3-methoxybenzeneethanamine;Benzeneethanamine, 4-ethoxy-3-methoxy-;MEPEA;UNII-P4MS942R6J;SCHEMBL1251843;DTXSID40189904;4-ethoxy-3-methoxy phenethylamine;MFCD00079756;AKOS000277603;2-(4-ethoxy-3-methoxy-phenyl)ethanamine;2-(4-ethoxy-3-methoxy-phenyl)-ethylamine;2-(4-Ethoxy-3-methoxyphenyl)ethanamine #;FT-0676190;PHENETHYLAMINE, 4-ETHOXY-3-METHOXY-;EN300-1851163;A823220;Q4634158

Chemical Property of 4-Ethoxy-3-methoxyphenethylamine

Chemical Property:

• Vapor Pressure: 0.00154mmHg at 25°C
• Refractive Index: 1.513
• Boiling Point: 295.3 °C at 760 mmHg
• PKA: 9.75±0.10(Predicted)
• Flash Point: 144.1 °C
• PSA: 44.48000
• Density: 1.025 g/cm³
• LogP: 2.29540
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 195.125928785
• Heavy Atom Count: 14
• Complexity: 152

Purity/Quality:

99% ^*data from raw suppliers

4-Ethoxy-3-methoxyphenethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C=C(C=C1)CCN)OC

Technology Process of 4-Ethoxy-3-methoxyphenethylamine

There total 13 articles about 4-Ethoxy-3-methoxyphenethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-ethoxy-3-methoxybenzylcyanide (103796-52-7) → 2-(4-ethoxy-3-methoxyphenyl)ethylamine (36377-59-0)

Guidance literature:

With ammonia; nickel; at 120 - 140 ℃; under 91938.4 Torr; Hydrogenation;

DOI:10.1021/ja01166a009

Reference yield:

4-ethoxy-3-methoxy-β-nitro-styrene (54110-88-2) → 2-(4-ethoxy-3-methoxyphenyl)ethylamine (36377-59-0)

Guidance literature:

at 65 ℃; bei der elektrolytischen Reduktion;

Reference yield:

3-(4-ethoxy-3-methoxy-phenyl)-propionic acid amide (858783-47-8) → 2-(4-ethoxy-3-methoxyphenyl)ethylamine (36377-59-0)

Guidance literature:

With potassium hypobromite;

DOI:10.1021/ja01152a057

upstream raw materials:

4-ethoxy-3-methoxy-β-nitro-styrene

4-ethoxy-3-methoxybenzylcyanide

3-(4-ethoxy-3-methoxy-phenyl)-propionic acid amide

3-(4-ethoxy-3-methoxy-phenyl)-propionic acid hydrazide

Downstream raw materials:

7-ethoxy-6-methoxy-1,2,3,4-tetrahydro-isoquinoline; hydrochloride

benzo[1,3]dioxol-5-yl-acetic acid-(4-ethoxy-3-methoxy-phenethylamide)

3,4-diethoxy-benzoic acid-(4-ethoxy-3-methoxy-phenethylamide)

(3-methoxy-2-nitro-phenyl)-acetic acid-(4-ethoxy-3-methoxy-phenethylamide)

Refernces

• 1、 -. "COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING NASH, NAFLD, AND OBESITY". Paragraph 00285; 00287. . Retrieved 2021/04/10.
• 2、 -. "CORYDALINE DERIVATIVES USEFUL FOR REDUCING LIPID LEVELS". Page/Page column 118. . Retrieved 2010/07/09.