Chlorhexidine Diacetate

Base Information

• Chemical Name: Chlorhexidine Diacetate
• CAS No.: 56-95-1
• Molecular Formula: C22H30Cl2N10^.2C2H4O2
• Molecular Weight: 625.558
• Hs Code.: 2925294500
• European Community (EC) Number: 200-302-4
• Mol file: 56-95-1.mol

Synonyms:Biguanide,1,1'-hexamethylenebis[5-(p-chlorophenyl)-, diacetate (6CI,7CI,8CI);1,6-Bis(p-chlorophenylbiguanido)hexane diacetate;Arlacide A;Bactigras;Chlorasept 2000;Chlorhexidine diacetate;Chlorzoin;Dosisepsine;EC 40;EC 40 (antibacterial);Hibitane diacetate;Chlorhexidine diacetate;NSC 526936;

Chemical Property of Chlorhexidine Diacetate

Chemical Property:

• Appearance/Colour: A white or almost white microcrystalline powder
• Melting Point: 153-156oC
• Boiling Point: 699.3 °C at 760 mmHg
• Flash Point: 376.7 °C
• PSA: 204.88000
• LogP: 6.37470
• Storage Temp.: room temp
• Solubility.: H2O: 15 mg/mL, clear
• Water Solubility.: 1.9 g/100 mL (20 ºC)
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 13
• Exact Mass: 624.2454551
• Heavy Atom Count: 42
• Complexity: 680

Purity/Quality:

90%,98% ^*data from raw suppliers

Chlorhexidine Diacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi,N
• Statements: 22-43-36/37/38-50/53
• Safety Statements: 36/37-36-26-61-60

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Uses -> Biocides/Disinfectants
• Canonical SMILES: CC(=O)O.CC(=O)O.C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl
• Recent ClinicalTrials: Antibacterial Effect and Clinical Performance of Chitosan Modified Glass Ionomer
• Recent EU Clinical Trials: Phase IV Open-label Pharmaco-economic and Practice Management Study of a New Preventive Treatment for Adult Caries in the U.K. and Germany
• Uses: antimicrobial agent in, e.g., cosmetic and disinfection solutions, eye drops, uterine antiseptics, toothpaste, mouthwash, hand and wound deansers. Chlorhexidine Diacetate is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. Chlorhexidine is a cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria. It has both bactericidal and bacteriostatic mechanisms of action. Aqueous solutions of chlorhexidine are most stable within the pH range of 5-8. Above pH 8.0 chlorhexidine base is precipitated and in more acid conditions there is gradual deterioration of activity because the compound is less stable. Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.