Technology Process of 5-Chloro-2-ethoxy-N-[4-(4-fluoro-benzyl)-morpholin-2-ylmethyl]-4-formylamino-benzamide
There total 9 articles about 5-Chloro-2-ethoxy-N-[4-(4-fluoro-benzyl)-morpholin-2-ylmethyl]-4-formylamino-benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 4 steps
1: H2, AcOH / 10percent Pd/C / ethanol / 60 °C
2: K2CO3, KI / butan-2-one / 17 h / Heating
3: 10percent HCl / 4 h / Heating
4: 1-ethyl-3-<3-dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature
With
hydrogenchloride; hydrogen; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide;
palladium on activated charcoal;
In
ethanol; dichloromethane; butanone;
DOI:10.1021/jm00106a023
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 97 percent / K2CO3 / dimethylformamide / 6 h / 50 °C
2: 97 percent / N-chlorosuccinimide (NCS) / dimethylformamide / 2 h / 70 °C
3: 99 percent / NaOH, H2O / ethanol / 5 h / Heating
4: 91 percent / thionyl chloride / 4 h / 0 - 20 °C
5: 94 percent / acetic anhydride / 2.5 h / 50 °C
6: 82 percent / NaOH, H2O / ethanol / 1 h / 60 °C
7: 1-ethyl-3-<3-dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature
With
sodium hydroxide; N-chloro-succinimide; thionyl chloride; water; acetic anhydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00106a023
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 99 percent / NaOH, H2O / ethanol / 5 h / Heating
2: 91 percent / thionyl chloride / 4 h / 0 - 20 °C
3: 94 percent / acetic anhydride / 2.5 h / 50 °C
4: 82 percent / NaOH, H2O / ethanol / 1 h / 60 °C
5: 1-ethyl-3-<3-dimethylamino)propyl>carbodiimide hydrochloride / CH2Cl2 / 4 h / Ambient temperature
With
sodium hydroxide; thionyl chloride; water; acetic anhydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
ethanol; dichloromethane;
DOI:10.1021/jm00106a023