Technology Process of 1-(1-methyl(2-pyrrolino[2,3-d]pyridin-7-yl))-2-(phenylmethoxy)naphthalene
There total 11 articles about 1-(1-methyl(2-pyrrolino[2,3-d]pyridin-7-yl))-2-(phenylmethoxy)naphthalene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
In
ethanol; water; toluene;
for 24h;
Heating;
DOI:10.1016/S0040-4039(98)01951-0
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.75 g / CH2Cl2 / 3 h / 20 °C
2: 11.0 g / diisobutylaluminum hydride / CH2Cl2 / 20 h / Heating
3: 81 percent / N-bromosuccinimide / dimethylformamide / 1.5 h / 0 °C
4: 2.09 g
With
N-Bromosuccinimide; diisobutylaluminium hydride;
In
dichloromethane; N,N-dimethyl-formamide;
1: Acylation / 2: Reduction / 3: Bromination;
DOI:10.1021/jo991011h
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 38.6 g / CH2Cl2; H2O / 0.42 h / 20 °C
2.1: t-butyllithium / tetrahydrofuran; pentane / 3.5 h / -78 - -15 °C
2.2: 75 percent / tetrahydrofuran; pentane / 2 h / -78 - 20 °C
3.1: 100 percent / triethylamine; methanesulfonyl chloride / CH2Cl2 / 2 h / -10 - 20 °C
4.1: 11.0 g / diisobutylaluminum hydride / CH2Cl2 / 20 h / Heating
5.1: 81 percent / N-bromosuccinimide / dimethylformamide / 1.5 h / 0 °C
6.1: 2.09 g
With
N-Bromosuccinimide; tert.-butyl lithium; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; pentane;
1.1: Acylation / 2.1: Metallation / 2.2: Alkylation / 3.1: Cyclization / 4.1: Reduction / 5.1: Bromination;
DOI:10.1021/jo991011h