3-(4-chlorophenyl)-2-oxobutyl acetate

Base Information

• Chemical Name: 3-(4-chlorophenyl)-2-oxobutyl acetate
• CAS No.: 1067187-78-3
• Molecular Formula: C₁₂H₁₃ClO₃
• Molecular Weight: 240.686
• Mol file: 1067187-78-3.mol

Synonyms:3-(4-chlorophenyl)-2-oxobutyl acetate

Chemical Property of 3-(4-chlorophenyl)-2-oxobutyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-(4-chlorophenyl)-2-oxobutyl acetate

There total 3 articles about 3-(4-chlorophenyl)-2-oxobutyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

1-chloro-3-(4-chlorophenyl)butan-2-one (1067187-77-2) + acetic acid (64-19-7,77671-22-8) → 3-(4-chlorophenyl)-2-oxobutyl acetate (1067187-78-3)

Guidance literature:

With triethylamine; In acetone; at 0 - 25 ℃; for 48h;

Reference yield:

2-(4-Chloro-phenyl)-propionic acid (938-95-4) → 3-(4-chlorophenyl)-2-oxobutyl acetate (1067187-78-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1.5 h / 25 °C

2.1: tetrahydrofuran; diethyl ether / 0 - 25 °C

2.2: 1.08 h / 0 °C

3.1: triethylamine / acetone / 48 h / 0 - 25 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; acetone;

Reference yield:

α-methyl 4-chlorophenylacetyl chloride (63327-24-2) → 3-(4-chlorophenyl)-2-oxobutyl acetate (1067187-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran; diethyl ether / 0 - 25 °C

1.2: 1.08 h / 0 °C

2.1: triethylamine / acetone / 48 h / 0 - 25 °C

With triethylamine; In tetrahydrofuran; diethyl ether; acetone;

upstream raw materials:

1-chloro-3-(4-chlorophenyl)butan-2-one

acetic acid

2-(4-Chloro-phenyl)-propionic acid

α-methyl 4-chlorophenylacetyl chloride

Downstream raw materials:

2-(1-(4-chlorophenyl)ethyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid

Refernces