ethyl 3-bromo-4-trifluoroacetamidobenzoate

Base Information

• Chemical Name: ethyl 3-bromo-4-trifluoroacetamidobenzoate
• CAS No.: 160425-34-3
• Molecular Formula: C₁₁H₉BrF₃NO₃
• Molecular Weight: 340.097
• Mol file: 160425-34-3.mol

Synonyms:ethyl 3-bromo-4-trifluoroacetamidobenzoate

Chemical Property of ethyl 3-bromo-4-trifluoroacetamidobenzoate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 3-bromo-4-trifluoroacetamidobenzoate

There total 1 articles about ethyl 3-bromo-4-trifluoroacetamidobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl 3-bromo-4-aminobenzoate (7149-03-3) + trifluoroacetic anhydride (407-25-0) → ethyl 3-bromo-4-trifluoroacetamidobenzoate (160425-34-3)

Guidance literature:

In dichloromethane; for 5h; Ambient temperature;

DOI:10.1071/CH9942109

Reference yield: 95.0%

ethyl 3-bromo-4-trifluoroacetamidobenzoate (160425-34-3) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → 3-Bromo-4-((E)-2-ethoxycarbonyl-1-trifluoromethyl-vinylamino)-benzoic acid ethyl ester

Guidance literature:

In toluene; Heating;

DOI:10.1039/cc9960002253

Reference yield:

ethyl 3-bromo-4-trifluoroacetamidobenzoate (160425-34-3) → 4-((E)-2-Ethoxycarbonyl-1-trifluoromethyl-vinylamino)-benzoic acid ethyl ester (183989-92-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / toluene / Heating

2: 31 percent / tripropylamine / Pd(OAc)2, PPh₃ / dimethylformamide / Heating

With tri-n-propylamine; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; toluene;

upstream raw materials:

ethyl 3-bromo-4-aminobenzoate

trifluoroacetic anhydride

Downstream raw materials:

4-((E)-2-Ethoxycarbonyl-1-trifluoromethyl-vinylamino)-benzoic acid ethyl ester

Refernces