2-(3-chlorophenyl)acetyl chloride

Base Information

• Chemical Name: 2-(3-chlorophenyl)acetyl chloride
• CAS No.: 41904-39-6
• Molecular Formula: C₈H₆Cl₂O
• Molecular Weight: 189.041
• Mol file: 41904-39-6.mol

Synonyms:3-chloro-benzeneacetyl chloride

Chemical Property of 2-(3-chlorophenyl)acetyl chloride

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(3-Chlorophenyl)acetylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(3-Chlorophenyl)acetyl chloride is a novel pyrrolidine MCHR1 antagonists and reduce hERG inhibition.

Technology Process of 2-(3-chlorophenyl)acetyl chloride

There total 9 articles about 2-(3-chlorophenyl)acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-chlorophenylacetic acid (1878-65-5) → 3-chloro-benzeneacetyl chloride (41904-39-6)

Guidance literature:

With thionyl chloride; In dichloromethane;

DOI:10.1016/j.bmcl.2007.09.036

Reference yield:

methyl 3-chlorophenylacetate (53088-68-9) → 3-chloro-benzeneacetyl chloride (41904-39-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; tetra-(n-butyl)ammonium iodide / toluene / 5 h / 90 °C

2: sodium hydroxide; water / 100 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C / Inert atmosphere

With oxalyl dichloride; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane; toluene;

DOI:10.1021/jacs.8b13052

Reference yield:

2-(3-chlorophenyl)acrylic acid (107473-99-4) → 3-chloro-benzeneacetyl chloride (41904-39-6)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.8b13052

upstream raw materials:

3-chlorophenylacetic acid

2-diazo-1-(3-chlorophenyl)ethanone

m-Chlorobenzoyl chloride

3-chlorobenzoate

Downstream raw materials:

2-(3-chlorophenyl)-N,N-dimethylacetamide

3-chlorobenzyl 2-thienyl ketone

5-chloro-3,4-dihydro-1H-naphthalen-2-one

7-chloro-3,4-dihydro-2(1H)-naphthalenone

Refernces

• 1、 -. "Pentuline derivatives and preparation methods and applications thereof". Paragraph 0054-0056. . Retrieved 2022/01/12.
• 2、 -. "CDPK1 INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO". Paragraph 0184-0186. . Retrieved 2021/11/13.