N-benzyl-N-methyl-4-phenylbutan-2-amine

Base Information

• Chemical Name: N-benzyl-N-methyl-4-phenylbutan-2-amine
• CAS No.: 1380487-91-1
• Molecular Formula: C₁₈H₂₃N
• Molecular Weight: 253.387
• Mol file: 1380487-91-1.mol

Synonyms:N-benzyl-N-methyl-4-phenylbutan-2-amine

Chemical Property of N-benzyl-N-methyl-4-phenylbutan-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-N-methyl-4-phenylbutan-2-amine

There total 7 articles about N-benzyl-N-methyl-4-phenylbutan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-Phenyl-2-butanone (2550-26-7) + benzyl-methyl-amine (103-67-3) → N-benzyl-N-methyl-4-phenylbutan-2-amine (1380487-91-1)

Guidance literature:

With ammonium hexafluorophosphate; trimethylamine-N-oxide; (2,4-bis(triisopropylsilyl)-7-N-tosylbicyclo[3.3.0]hepta-1,4-dien-3-one)iron tricarbonyl; hydrogen; In methanol; at 100 ℃; for 17.5h; under 3750.38 Torr; Reagent/catalyst; Autoclave; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201302432

Reference yield: 60.0%

N-benzyl-1-methyl-3-phenylpropylamine (68164-04-5) + dimethyl sulfoxide (67-68-5,8070-53-9) → N-benzyl-N-methyl-4-phenylbutan-2-amine (1380487-91-1)

Guidance literature:

With formic acid; triethylamine; at 150 ℃; for 12h; Inert atmosphere; Green chemistry;

DOI:10.1002/chem.201303802

Reference yield:

1-phenyl-3-butanol (2344-70-9) → N-benzyl-N-methyl-4-phenylbutan-2-amine (1380487-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylsilyl iodide / dichloromethane / 16 h / 20 °C

2: acetonitrile / 100 °C

With trimethylsilyl iodide; In dichloromethane; acetonitrile;

DOI:10.1002/ejoc.202001602

upstream raw materials:

4-Phenyl-2-butanone

benzyl-methyl-amine

N-benzyl-1-methyl-3-phenylpropylamine

dimethyl sulfoxide

Refernces

• 1、 Mahamudul Hassan, Mirja Md,Mondal, Biplab,Singh, Sukriti,Haldar, Chabush,Chaturvedi, Jagriti,Bisht, Ranjana,Sunoj, Raghavan B.,Chattopadhyay, Buddhadeb. "Ir-Catalyzed Ligand-Free Directed C-H Borylation of Arenes and Pharmaceuticals: Detailed Mechanistic Understanding". supporting information. p. 4360 - 4375. Retrieved 2022/03/16.
• 2、 Jiang, Xue,Wang, Chao,Wei, Yawen,Xue, Dong,Liu, Zhaotie,Xiao, Jianliang. "A general method for N-methylation of amines and nitro compounds with dimethylsulfoxide". supporting information. p. 58 - 63. Retrieved 2014/01/17.