Technology Process of N-[(1-methylpiperidin-2-yl)methyl]-N-phenylindan-2-yl-amine
There total 8 articles about N-[(1-methylpiperidin-2-yl)methyl]-N-phenylindan-2-yl-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C / Cooling with ice
2.1: sodium amide / toluene / 3 h / 0 - 20 °C
2.2: 16 h / Reflux
3.1: ammonium formate / palladium 10% on activated carbon / methanol / 3 h / Reflux; Inert atmosphere
4.1: acetic acid; sodium tris(acetoxy)borohydride / water; 1,2-dichloro-ethane / 16 h / 20 °C
With
ammonium formate; sodium tris(acetoxy)borohydride; sodium amide; acetic acid;
palladium 10% on activated carbon;
In
methanol; dichloromethane; water; 1,2-dichloro-ethane; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 20 °C / Cooling with ice
2.1: sodium amide / toluene / 3 h / 0 - 20 °C
2.2: 16 h / Reflux
3.1: ammonium formate / palladium 10% on activated carbon / methanol / 3 h / Reflux; Inert atmosphere
4.1: acetic acid; sodium tris(acetoxy)borohydride / water; 1,2-dichloro-ethane / 16 h / 20 °C
With
ammonium formate; sodium tris(acetoxy)borohydride; sodium amide; acetic acid;
palladium 10% on activated carbon;
In
methanol; dichloromethane; water; 1,2-dichloro-ethane; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C
2.1: thionyl chloride / chloroform / 2 h / 0 °C / Reflux
3.1: sodium amide / toluene / 3 h / 0 - 20 °C
3.2: 16 h / Reflux
4.1: ammonium formate / palladium 10% on activated carbon / methanol / 3 h / Reflux; Inert atmosphere
5.1: acetic acid; sodium tris(acetoxy)borohydride / water; 1,2-dichloro-ethane / 16 h / 20 °C
With
thionyl chloride; ammonium formate; sodium tris(acetoxy)borohydride; potassium carbonate; sodium amide; acetic acid;
palladium 10% on activated carbon;
In
methanol; chloroform; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;