6-chloro-4-phenylquinazoline

Base Information

• Chemical Name: 6-chloro-4-phenylquinazoline
• CAS No.: 4015-28-5
• Molecular Formula: C₁₄H₉ClN₂
• Molecular Weight: 240.692
• Mol file: 4015-28-5.mol

Synonyms:6-chloro-4-phenylquinazoline

Chemical Property of 6-chloro-4-phenylquinazoline

Chemical Property:

Purity/Quality:

6-CHLORO-4-PHENYLQUINAZOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 6-Chloro-4-phenylquinazoline is an intermediate in the synthesis of 6-chloro1,4-dihydro-1-methyl-4-phenyl-4-quinazolinol (C371025)..

Technology Process of 6-chloro-4-phenylquinazoline

There total 34 articles about 6-chloro-4-phenylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-chloro-2-aminobenzophenone (719-59-5) + glycine (56-40-6,18875-39-3,25718-94-9) → 6-chloro-4-phenylquinazoline (4015-28-5)

Guidance literature:

With tert.-butylhydroperoxide; iodine; In ISOPROPYLAMIDE; water; at 80 ℃; for 4h; Sealed tube;

DOI:10.1039/c1cc12885j

Reference yield: 98.0%

N,N,N,N,-tetramethylethylenediamine (110-18-9) + 5-chloro-2-aminobenzophenone (719-59-5) → 6-chloro-4-phenylquinazoline (4015-28-5)

Guidance literature:

With iodine; oxygen; ammonium chloride; In dimethyl sulfoxide; at 120 ℃; for 20h; under 760.051 Torr;

DOI:10.1021/acs.joc.5b00474

Reference yield: 98.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) + 5-chloro-2-aminobenzophenone (719-59-5) → 6-chloro-4-phenylquinazoline (4015-28-5)

Guidance literature:

With tert.-butylhydroperoxide; N-iodo-succinimide; ammonia; In water; at 120 ℃; for 4h;

DOI:10.1002/anie.201203880

upstream raw materials:

(Z)-2-Amino-5-chlorbenzophenonamidinohydrazon-acetat

(E)-2-Amino-5-chlorbenzophenonamidinohydrazon-acetat

6-chloro-4-phenylquinazoline-2-carboxylic acid

6-chloro-1,2-dihydro-4-phenylquinazoline-2-carboxylic acid

Downstream raw materials:

1-(6-chloro-4-phenylquinazolin-2-yl)ethan-1-one

Refernces

• 1、 Satish, Gandhesiri,Polu, Ashok,Kota, Laxman,Ilangovan, Andivelu. "Copper-catalyzed oxidative amination of methanol to access quinazolines". . p. 4774 - 4782. Retrieved 2019/05/24.
• 2、 Yuan, Shuo,Yu, Bin,Liu, Hong-Min. "“On-Water” Palladium-Catalyzed Tandem Cyclization Reaction for the Synthesis of Biologically Relevant 4-Arylquinazolines". supporting information. p. 13109 - 13113. Retrieved 2019/10/22.