benzyl hept-6-ynoate

Base Information

• Chemical Name: benzyl hept-6-ynoate
• CAS No.: 528598-90-5
• Molecular Formula: C₁₄H₁₆O₂
• Molecular Weight: 216.28
• Mol file: 528598-90-5.mol

Synonyms:benzyl hept-6-ynoate

Chemical Property of benzyl hept-6-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl hept-6-ynoate

There total 2 articles about benzyl hept-6-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

hept-6-ynoic acid (30964-00-2) + benzyl bromide (100-39-0) → benzyl hept-6-ynoate (528598-90-5)

Guidance literature:

hept-6-ynoic acid; With caesium carbonate; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

benzyl bromide; In water; N,N-dimethyl-formamide; for 15h;

DOI:10.1002/adsc.201400057

Reference yield: 84.0%

hept-6-ynoic acid (30964-00-2) + benzyl alcohol (100-51-6,185532-71-2) → benzyl hept-6-ynoate (528598-90-5)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 44h;

DOI:10.1002/chem.200800535

Reference yield: 96.0%

(aR,7S)-7-azido-1,2,3,10-tetramethoxy-6,7-dihydrobenzo[a]heptalene-9(5H)-one (1233709-95-9) + benzyl hept-6-ynoate (528598-90-5) → C34H37N3O7

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 85 ℃; for 0.416667h; Microwave irradiation; Sealed tube;

DOI:10.1021/acsmedchemlett.5b00418

upstream raw materials:

hept-6-ynoic acid

benzyl bromide

benzyl alcohol

Downstream raw materials:

7-[3-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenyl]-hept-6-ynoic acid benzyl ester

benzyl hept-6-enoate

oenanthic acid

2-[4-benzyloxycarbonyl]butyltrifluoromethylacetylene

Refernces

• 1、 Tresse, Cedric,Guissart, Celine,Schweizer, Stephane,Bouhoute, Yassine,Chany, Anne-Caroline,Goddard, Mary-Lorene,Blanchard, Nicolas,Evano, Gwilherm. "Practical methods for the synthesis of trifluoromethylated alkynes: Oxidative trifluoromethylation of copper acetylides and alkynes". supporting information. p. 2051 - 2060. Retrieved 2014/07/07.
• 2、 Chan, David C. M.,Fu, Hongning,Forsch, Ronald A.,Queener, Sherry F.,Rosowsky, Andre. "Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with ω-carboxyalkoxy or ω-carboxy-1-alkynyl substitution in the side chain". . p. 4420 - 4431. Retrieved 2007/10/03.