2,6-diethyl-4-fluorobenzenamine

Base Information

• Chemical Name: 2,6-diethyl-4-fluorobenzenamine
• CAS No.: 117336-04-6
• Molecular Formula: C₁₀H₁₄FN
• Molecular Weight: 167.226
• Mol file: 117336-04-6.mol

Synonyms:2,6-diethyl-4-fluorobenzenamine

Chemical Property of 2,6-diethyl-4-fluorobenzenamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-diethyl-4-fluorobenzenamine

There total 3 articles about 2,6-diethyl-4-fluorobenzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

triethyl borane (97-94-9) + 2,6-dibromo-4-fluoroaniline (344-18-3) → 2,6-diethyl-4-fluorobenzenamine (117336-04-6)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In hexane; N,N-dimethyl-formamide; at 50 ℃; for 22h;

DOI:10.1021/jm990170q

Reference yield:

4-fluoroaniline (371-40-4) → 2,6-diethyl-4-fluorobenzenamine (117336-04-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.04 g / Br₂ / CH₂Cl₂

2: 64 percent / (dppf)PdCl₂, CsCO₃ / dimethylformamide; hexane / 22 h / 50 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bromine; In hexane; dichloromethane; N,N-dimethyl-formamide; 1: Bromination / 2: ethylation;

DOI:10.1021/jm990170q

Reference yield:

→ 2,6-diethyl-4-fluorobenzenamine (117336-04-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h;

upstream raw materials:

triethyl borane

2,6-dibromo-4-fluoroaniline

4-fluoroaniline

Downstream raw materials:

2-bromo-N-(2,6-diethyl-4-fluoro-phenyl)-acetamide

Refernces

• 1、 -. "COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY". Page/Page column 191; 192. . Retrieved 2017/11/15.