5-(2-acetylphenyl)pent-4-ynenitrile

Base Information

• Chemical Name: 5-(2-acetylphenyl)pent-4-ynenitrile
• CAS No.: 1266340-40-2
• Molecular Formula: C₁₃H₁₁NO
• Molecular Weight: 197.236
• Mol file: 1266340-40-2.mol

Synonyms:5-(2-acetylphenyl)pent-4-ynenitrile

Chemical Property of 5-(2-acetylphenyl)pent-4-ynenitrile

Chemical Property:

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Technology Process of 5-(2-acetylphenyl)pent-4-ynenitrile

There total 1 articles about 5-(2-acetylphenyl)pent-4-ynenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

pent-4-ynenitrile (19596-07-7) + 2-bromophenyl methyl ketone (2142-69-0) → 5-(2-acetylphenyl)pent-4-ynenitrile (1266340-40-2)

Guidance literature:

2-bromophenyl methyl ketone; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 25 ℃; for 0.25h; Inert atmosphere;

pent-4-ynenitrile; at 60 ℃; for 11h; Inert atmosphere;

DOI:10.1021/ol1029047

upstream raw materials:

pent-4-ynenitrile

2-bromophenyl methyl ketone

Refernces