2'-DEOXYGUANOSINE 5'-MONOPHOSPHATE

Base Information

• Chemical Name: 2'-DEOXYGUANOSINE 5'-MONOPHOSPHATE
• CAS No.: 902-04-5
• Molecular Formula: C10H14 N5 O7 P
• Molecular Weight: 347.224
• Mol file: 902-04-5.mol

Synonyms:Guanosine,2'-deoxy-, 5'-(dihydrogen phosphate) (8CI); Guanosine, 2'-deoxy-, 5'-phosphate(6CI); Guanosine, 2'-deoxy-, phosphate (7CI); 2'-Deoxy-5'-GMP;2'-Deoxy-5'-guanylic acid; 2'-Deoxy-GMP; 2'-Deoxyguanosine 5'-monophosphate;2'-Deoxyguanosine 5'-phosphate; 2'-Deoxyguanylic acid; 2'-dGMP; Deoxy-GMP;Deoxyguanosine 5'-monophosphate; Deoxyguanosine 5'-phosphate; NSC 82626; dGMP

Chemical Property of 2'-DEOXYGUANOSINE 5'-MONOPHOSPHATE

Chemical Property:

• Melting Point: 180-182oC
• Boiling Point: 844.2°Cat760mmHg
• PKA: 1.86±0.10(Predicted)
• Flash Point: 464.4°C
• PSA: 195.62000
• Density: 2.32g/cm³
• LogP: -0.95930
• Storage Temp.: −20°C

Purity/Quality:

99%, ^*data from raw suppliers

2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DISODIUM SALT 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-DEOXYGUANOSINE 5'-MONOPHOSPHATE

There total 25 articles about 2'-DEOXYGUANOSINE 5'-MONOPHOSPHATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2'-Deoxyguanosine (961-07-9) → 2'-deoxyguanosine 5'-monophosphate (902-04-5)

Guidance literature:

2'-Deoxyguanosine; With trichlorophosphate; at 20 ℃; for 0.15h; Flow reactor; Green chemistry;

With water; at 20 ℃; Temperature; chemoselective reaction; Flow reactor; Green chemistry;

DOI:10.1021/op5002066

Reference yield:

5'-GGTGGTGGTGGTTGTGGTGGTGGTGG-3' → 2-amino-1,9-dihydro-6H-purin-6-one (73-40-5) + 2'-Deoxyguanosine (961-07-9) + 2'-deoxyguanosine 5'-monophosphate (902-04-5)

Guidance literature:

With 10 percent fetal bovine serum; In aq. phosphate buffer; at 37 ℃; for 96h;

DOI:10.1039/c4sc03949a

Reference yield:

5'-CTGGGTTGGGTTGGGTTGGGA-3' → 2-amino-1,9-dihydro-6H-purin-6-one (73-40-5) + 2'-Deoxyguanosine (961-07-9) + 2'-deoxyguanosine 5'-monophosphate (902-04-5)

Guidance literature:

With 10 percent fetal bovine serum; In aq. phosphate buffer; at 37 ℃; for 96h;

DOI:10.1039/c4sc03949a

upstream raw materials:

phosphoric acid monophenyl ester

2'-Deoxyguanosine

N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid

2'-deoxyguanosine 5'-triphosphate

Downstream raw materials:

2'-Deoxyguanosine

7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydrobenzopyrene

methanol

2-amino-1,9-dihydro-6H-purin-6-one

Refernces

• 1、 Kanavarioti, Anastassia,Gangopadhyay, Sumana. "Kinetics of Template-Directed Pyrophosphate-Linked Dideoxyguanylate Synthesis as a Function of 2-MeImpdG and Poly(C) Concentration: Insights into the Mechanism". . p. 7957 - 7964. Retrieved 1999.
• 2、 Arichi, Norihito,Yamamoto, Junpei,Takahata, Chiaki,Sano, Emi,Masuda, Yuji,Kuraoka, Isao,Iwai, Shigenori. "Strand breakage of a (6-4) photoproduct-containing DNA at neutral pH and its repair by the ERCC1-XPF protein complex". . p. 3526 - 3534. Retrieved 2013.
• 3、 Zhu, Chenjie,Tang, Chenglun,Cao, Zhi,He, Wei,Chen, Yong,Chen, Xiaochun,Guo, Kai,Ying, Hanjie. "Fully automated continuous meso-flow synthesis of 5′-nucleotides and deoxynucleotides". . p. 1575 - 1581. Retrieved 2015/02/19.