Technology Process of methyl 4-ethynyl-2,3-dimethylbenzoate
There total 4 articles about methyl 4-ethynyl-2,3-dimethylbenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 25 ℃;
for 2h;
Inert atmosphere;
DOI:10.1039/c3cc38676g
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane / dimethyl sulfoxide / 1.33 h / 70 °C / Inert atmosphere
2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; diisopropylamine / N,N-dimethyl-formamide / 2.5 h / 25 - 80 °C / Inert atmosphere
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 25 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; 1,3-bis-(diphenylphosphino)propane; tetrabutyl ammonium fluoride; palladium diacetate; triethylamine; diisopropylamine;
In
tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
2: |Sonogashira Cross-Coupling;
DOI:10.1039/c3cc38676g
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine / dichloromethane / 2 h / 0 - 25 °C / Inert atmosphere
2: triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane / dimethyl sulfoxide / 1.33 h / 70 °C / Inert atmosphere
3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; diisopropylamine / N,N-dimethyl-formamide / 2.5 h / 25 - 80 °C / Inert atmosphere
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 25 °C / Inert atmosphere
With
pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; 1,3-bis-(diphenylphosphino)propane; tetrabutyl ammonium fluoride; palladium diacetate; triethylamine; diisopropylamine;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
3: |Sonogashira Cross-Coupling;
DOI:10.1039/c3cc38676g