C₁₅H₁₂FN

Base Information

• Chemical Name: C₁₅H₁₂FN
• CAS No.: 1234513-16-6
• Molecular Formula: C₁₅H₁₂FN
• Molecular Weight: 225.265
• Mol file: 1234513-16-6.mol

Synonyms:C₁₅H₁₂FN

Chemical Property of C₁₅H₁₂FN

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₅H₁₂FN

There total 5 articles about C₁₅H₁₂FN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

acetophenone O-acetyloxime (19433-17-1) + 1-fluoro-3-iodo-2-methylbenzene (443-85-6) → C15H12FN (1234513-16-6)

Guidance literature:

With norborn-2-ene; trifuran-2-yl-phosphane; palladium diacetate; potassium carbonate; In 1,4-dioxane; dimethyl sulfoxide; at 80 ℃; for 24h; Inert atmosphere;

Reference yield: 87.0%

1-fluoro-3-iodo-2-methylbenzene (443-85-6) + (E)‐1‐phenylethan‐1‐one O‐acetyl oxime (19433-17-1) → C15H12FN (1234513-16-6)

Guidance literature:

With trifuran-2-yl-phosphane; norbornene; palladium diacetate; potassium carbonate; In 1,4-dioxane; dimethyl sulfoxide; at 80 ℃; for 24h; Schlenk technique;

DOI:10.1021/acs.orglett.1c03679

Reference yield: 55.0%

1-fluoro-3-iodo-2-methylbenzene (443-85-6) + 3-phenyl-2H-azirine (7654-06-0) → C15H12FN (1234513-16-6)

Guidance literature:

With norborn-2-ene; tri(m-chlorophenyl)-phosphine; palladium diacetate; caesium carbonate; In acetonitrile; at 110 ℃; for 16h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ol100975b

upstream raw materials:

1-fluoro-3-iodo-2-methylbenzene

3-phenyl-2H-azirine

acetophenone O-acetyloxime

acetophenone oxime

Refernces

• 1、 -. "Method for synthesizing 2-substituted indole compound from iodobenzene and oxime ester under catalysis of palladium". Paragraph 0319-0327. . Retrieved 2022/01/05.