diethyl 2,2-dipentylmalonate

Base Information

• Chemical Name: diethyl 2,2-dipentylmalonate
• CAS No.: 220776-75-0
• Molecular Formula: C₁₇H₃₂O₄
• Molecular Weight: 300.439
• Mol file: 220776-75-0.mol

Synonyms:diethyl 2,2-dipentylmalonate

Chemical Property of diethyl 2,2-dipentylmalonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2,2-dipentylmalonate

There total 1 articles about diethyl 2,2-dipentylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-Bromopentane (110-53-2) + diethyl malonate (105-53-3) → diethyl 2,2-dipentylmalonate (220776-75-0) + diethyl n-pentylmalonate (6065-59-4)

Guidance literature:

With sodium ethanolate; In ethanol;

DOI:10.1007/s11494-008-2008-2

Reference yield:

diethyl 2,2-dipentylmalonate (220776-75-0) → N1,N3-bis((R)-2-hydroxy-1-phenylethyl)-2,2-dipentylmalonamide (1246401-81-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / water; ethanol / Reflux

1.2: pH 1

2.1: oxalyl dichloride; N,N-dimethyl-formamide / benzene / 3 h / 0 °C / Reflux

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; potassium hydroxide; In ethanol; dichloromethane; water; benzene;

DOI:10.1021/acs.orglett.5b00131

Reference yield:

diethyl 2,2-dipentylmalonate (220776-75-0) → 2,2'-(1-pentylhexylidene)bis((R)-4,5-dihydro-4-phenyloxazole) (1246401-53-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / water; ethanol / Reflux

1.2: pH 1

2.1: oxalyl dichloride; N,N-dimethyl-formamide / benzene / 3 h / 0 °C / Reflux

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4.1: thionyl chloride / chloroform / 4 h / 0 - 70 °C

4.2: 4 h / Reflux

With thionyl chloride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; potassium hydroxide; In ethanol; dichloromethane; chloroform; water; benzene;

DOI:10.1021/acs.orglett.5b00131

upstream raw materials:

1-Bromopentane

diethyl malonate

Downstream raw materials:

2-pentyl-1-heptanol

N¹,N³-bis((R)-2-hydroxy-1-phenylethyl)-2,2-dipentylmalonamide

2,2'-(1-pentylhexylidene)bis((R)-4,5-dihydro-4-phenyloxazole)

Refernces