Technology Process of (4aS,9aS)-4a-cyanomethyl-9-(4-methylbenzenesulfonyl)-2,4a,9,9a-tetrahydro-1H-carbazole
There total 10 articles about (4aS,9aS)-4a-cyanomethyl-9-(4-methylbenzenesulfonyl)-2,4a,9,9a-tetrahydro-1H-carbazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: Pd2dba3*CHCl3; (S)-BINAPO / dimethylformamide / 21 h / 0 °C
2: 100 percent / aq. HCl / tetrahydrofuran / 1 h / 20 °C
3: 90 percent / PBr3 / tetrahydrofuran / 1.5 h / 0 - 20 °C
4: 95 percent / dimethylsulfoxide / 1 h / 20 °C
5: 73 percent / Pd(OAc)2; Me2PPh; Ag2CO3 / dimethylsulfoxide / 17 h / 90 °C
With
hydrogenchloride; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; palladium diacetate; phosphorus tribromide; silver carbonate; (S)-1,1'-binaphthalene-2,2'-diylbis(diphenylphosphine oxide); Dimethyl(phenyl)phosphine;
In
tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
5: Heck reaction;
DOI:10.1021/ja029382u
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 100 percent / aq. HCl / tetrahydrofuran / 1 h / 20 °C
2: 90 percent / PBr3 / tetrahydrofuran / 1.5 h / 0 - 20 °C
3: 95 percent / dimethylsulfoxide / 1 h / 20 °C
4: 73 percent / Pd(OAc)2; Me2PPh; Ag2CO3 / dimethylsulfoxide / 17 h / 90 °C
With
hydrogenchloride; palladium diacetate; phosphorus tribromide; silver carbonate; Dimethyl(phenyl)phosphine;
In
tetrahydrofuran; dimethyl sulfoxide;
4: Heck reaction;
DOI:10.1021/ja029382u
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 95 percent / dimethylsulfoxide / 1 h / 20 °C
2: 73 percent / Pd(OAc)2; Me2PPh; Ag2CO3 / dimethylsulfoxide / 17 h / 90 °C
With
palladium diacetate; silver carbonate; Dimethyl(phenyl)phosphine;
In
dimethyl sulfoxide;
2: Heck reaction;
DOI:10.1021/ja029382u