N-[3-acetoxy-2,2-dibenzylpropanoyl]-S-methyl-S-2-pyridylsulfoximine

Base Information

• Chemical Name: N-[3-acetoxy-2,2-dibenzylpropanoyl]-S-methyl-S-2-pyridylsulfoximine
• CAS No.: 1384980-66-8
• Molecular Formula: C₂₅H₂₆N₂O₄S
• Molecular Weight: 450.558
• Mol file: 1384980-66-8.mol

Synonyms:N-[3-acetoxy-2,2-dibenzylpropanoyl]-S-methyl-S-2-pyridylsulfoximine

Chemical Property of N-[3-acetoxy-2,2-dibenzylpropanoyl]-S-methyl-S-2-pyridylsulfoximine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3-acetoxy-2,2-dibenzylpropanoyl]-S-methyl-S-2-pyridylsulfoximine

There total 4 articles about N-[3-acetoxy-2,2-dibenzylpropanoyl]-S-methyl-S-2-pyridylsulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

N-[2,2-dibenzylpropanoyl]-S-methyl-S-2-pyridylsulfoximine (1384980-47-5) + acetic acid (64-19-7,77671-22-8) → N-[3-acetoxy-2,2-dibenzylpropanoyl]-S-methyl-S-2-pyridylsulfoximine (1384980-66-8)

Guidance literature:

With [bis(acetoxy)iodo]benzene; palladium diacetate; at 20 ℃; for 48h;

DOI:10.1021/ol301579q

Reference yield:

N-[3-acetoxy-2-benzyl-2-methylpropanoyl]-S-methyl-S-2-pyridylsulfoximine (1384980-70-4) → N-[3-acetoxy-2,2-dibenzylpropanoyl]-S-methyl-S-2-pyridylsulfoximine (1384980-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; water / 6 h / 50 °C

2.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.2: 12 h / 0 - 20 °C / Inert atmosphere

3.1: [bis(acetoxy)iodo]benzene; palladium diacetate / 48 h / 20 °C

With hydrogenchloride; [bis(acetoxy)iodo]benzene; water; palladium diacetate; triethylamine; In dichloromethane;

DOI:10.1021/ol301579q

Reference yield:

C17H17ClO + imino(methyl)(pyridin-2-yl)-λ6-sulfanone (76456-06-9) → N-[3-acetoxy-2,2-dibenzylpropanoyl]-S-methyl-S-2-pyridylsulfoximine (1384980-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 20 °C / Inert atmosphere

2.1: [bis(acetoxy)iodo]benzene; palladium diacetate / 48 h / 20 °C

With [bis(acetoxy)iodo]benzene; palladium diacetate; triethylamine; In dichloromethane;

DOI:10.1021/ol301579q

upstream raw materials:

N-[3-acetoxy-2-benzyl-2-methylpropanoyl]-S-methyl-S-2-pyridylsulfoximine

N-[2,2-dibenzylpropanoyl]-S-methyl-S-2-pyridylsulfoximine

acetic acid

imino(methyl)(pyridin-2-yl)-λ⁶-sulfanone

Refernces