C₁₂H₈N₂OS

Base Information

• Chemical Name: C₁₂H₈N₂OS
• CAS No.: 1426959-48-9
• Molecular Formula: C₁₂H₈N₂OS
• Molecular Weight: 228.274
• Mol file: 1426959-48-9.mol

Synonyms:C₁₂H₈N₂OS

Chemical Property of C₁₂H₈N₂OS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₈N₂OS

There total 3 articles about C₁₂H₈N₂OS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

2-hydroxy-3-cyano-5-bromopyridine (405224-22-8) + thiophenol (108-98-5) → C12H8N2OS (1426959-48-9)

Guidance literature:

With copper(l) iodide; caesium carbonate; In acetonitrile; Inert atmosphere; Reflux;

DOI:10.1016/j.ejmech.2012.12.016

Reference yield:

2-hydroxy-3-cyanopyridine (20577-27-9,95907-03-2) → C12H8N2OS (1426959-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / 3.5 h / 20 °C

2: caesium carbonate; copper(l) iodide / acetonitrile / Inert atmosphere; Reflux

With copper(l) iodide; bromine; caesium carbonate; In acetonitrile;

DOI:10.1016/j.ejmech.2012.12.016

Reference yield:

2-chloro-3-pyridinecarbonitrile (6602-54-6) → C12H8N2OS (1426959-48-9)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 8 h / 125 °C

2: bromine / 3.5 h / 20 °C

3: caesium carbonate; copper(l) iodide / acetonitrile / Inert atmosphere; Reflux

With copper(l) iodide; bromine; caesium carbonate; acetic acid; In acetonitrile;

DOI:10.1016/j.ejmech.2012.12.016

upstream raw materials:

2-hydroxy-3-cyano-5-bromopyridine

thiophenol

2-hydroxy-3-cyanopyridine

2-chloro-3-pyridinecarbonitrile

Refernces