4,4'-Methylenedibenzaldehyde

Base Information

• Chemical Name: 4,4'-Methylenedibenzaldehyde
• CAS No.: 67-37-8
• Molecular Formula: C₁₅H₁₂O₂
• Molecular Weight: 224.259
• DSSTox Substance ID: DTXSID601304423
• Nikkaji Number: J541.126B
• Mol file: 67-37-8.mol

Synonyms:4,4'-methylenedibenzaldehyde;67-37-8;4,4,-methylenedibenzaldehyde;4-[(4-formylphenyl)methyl]benzaldehyde;SCHEMBL3976211;4,4'-Methylenebis[benzaldehyde];DTXSID601304423

Chemical Property of 4,4'-Methylenedibenzaldehyde

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 224.083729621
• Heavy Atom Count: 17
• Complexity: 220

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)C=O)C=O

Technology Process of 4,4'-Methylenedibenzaldehyde

There total 15 articles about 4,4'-Methylenedibenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4,4'-dicyanodiphenylmethane (10466-37-2) → 4,4'-methylenedibenzaldehyde (67-37-8)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at 0 ℃;

DOI:10.1016/j.bmcl.2009.05.061

Reference yield: 48.0%

bis(4-bromomethylphenyl)methane (16980-01-1) → 4,4'-methylenedibenzaldehyde (67-37-8)

Guidance literature:

bis(4-bromomethylphenyl)methane; With hexamethylenetetramine; In chloroform; at 70 ℃; for 6h;

With acetic acid; at 110 ℃; for 6h; Further stages.;

DOI:10.1021/ja011493q

Reference yield: 35.0%

bis<4-(hydroxymethyl)phenyl>methane (14568-86-6) → 4,4'-methylenedibenzaldehyde (67-37-8)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane;

upstream raw materials:

bis<4-(hydroxymethyl)phenyl>methane

carbon monoxide

Diphenylmethane

4,4'-bis(chloromethyl)diphenylmethane

Downstream raw materials:

4,4'-methylenedibenzoic acid

bis<4-(hydroxymethyl)phenyl>methane

bis{4-((4R,5R)-4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl)phenyl}methane

4,4'-Methylendicinnamylalkohol-monomethylether

Refernces

• 1、 Hu, Laixing,Kully, Maureen L.,Boykin, David W.,Abood, Norman. "Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents". scheme or table. p. 3374 - 3377. Retrieved 2010/02/28.
• 2、 Tanaka, Mutsuo,Fujiwara, Masahiro,Xu, Qiang,Ando, Hisanori,Raeker, Todd J.. "Influence of Conformation and Proton-Transfer Dynamics in the Dibenzyl σ-Complex on Regioselectivity in Gattermann-Koch Formylation via Intracomplex Reaction". . p. 4408 - 4412. Retrieved 2007/10/03.