Meclofenamate sodium

Base Information

• Chemical Name: Meclofenamate sodium
• CAS No.: 6385-02-0
• Molecular Formula: C14H11 Cl2 N O2 . Na
• Molecular Weight: 318.135
• Hs Code.: 2922499990
• European Community (EC) Number: 228-983-3
• UNII: 9MMQ0YER4E
• DSSTox Substance ID: DTXSID8045567
• Nikkaji Number: J8.403D
• Wikidata: Q27107307
• NCI Thesaurus Code: C47597
• RXCUI: 6677
• Metabolomics Workbench ID: 67469
• ChEMBL ID: CHEMBL876
• Mol file: 6385-02-0.mol

Synonyms:Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt, monohydrate;Meclofenamate;Meclofenamate Sodium;Meclofenamate Sodium Anhydrous;Meclofenamate Sodium Monohydrate;Meclofenamate, Sodium;Meclofenamic Acid;Meclomen;Sodium Meclofenamate

Chemical Property of Meclofenamate sodium

Chemical Property:

• Vapor Pressure: 4.27E-07mmHg at 25°C
• Melting Point: 287-291 °C
• Boiling Point: 399.4oC at 760 mmHg
• Flash Point: 195.3oC
• PSA: 52.16000
• LogP: 3.48190
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 316.9986282
• Heavy Atom Count: 20
• Complexity: 332

Purity/Quality:

98%,99%, ^*data from raw suppliers

Meclofenamate Sodium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=C(C=C1)Cl)NC2=CC=CC=C2C(=O)[O-])Cl.[Na+]
• Recent EU Clinical Trials: Phase I/II trial of meclofenamate in progressive MGMT-methylated glioblastoma under temozolomide second-line therapy
• Description: Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 μM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.
• Uses: Meclofenamate Sodium is an NSAID used in the treatment of chronic pain. antiinflammatory, antipyretic
• Indications: Meclofenamate sodium (Meclomen) is prescribed for rheumatoid arthritis and osteoarthritis. The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs.
• Therapeutic Function: Antiinflammatory
• Clinical Use: Meclofenamate sodium is indicated for the relief of mild to moderate pain, the acute and chronic treatment of rheumatoid arthritis and osteoarthritis, the treatment of primary dysmenorrhea, and the treatment of idiopathic, heavy menstrual blood loss.

Technology Process of Meclofenamate sodium

There total 1 articles about Meclofenamate sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

meclofenamic acid ethyl ester → meclofenamate sodium (6385-02-0)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; ethanol; water;

DOI:10.1073/pnas.2009977117

Reference yield: 100.0%

N,N-dimethyl-N-benzyl-N-(2-methacryloyloxyethyl)ammonium bromide (157617-92-0) + meclofenamate sodium (6385-02-0) → N,N-dimethyl-N-benzyl-N-(2-methacryloyloxyethyl)ammonium meclofenamate (1345856-42-9)

Guidance literature:

In ethanol; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2011.08.004

Reference yield: 99.0%

Br(1-)*C19H24NO2(1+) (1192205-90-5) + meclofenamate sodium (6385-02-0) → C14H10Cl2NO2(1-)*C19H24NO2(1+) (1345856-48-5)

Guidance literature:

In ethanol; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2011.08.004

Downstream raw materials:

1-(2,6-dichloro-3-methyl-phenyl)-1,2-dihydro-benzo[d][1,3]oxazin-4-one

N,N-dimethyl-N-benzyl-N-(2-methacryloyloxyethyl)ammonium meclofenamate

C₁₄H₁₀Cl₂NO₂^(1-)*C₁₉H₂₄NO₂⁽¹⁺⁾

meclofenamic acid-isonicotinamide

Refernces