N-Ethylphthalimide

Base Information

• Chemical Name: N-Ethylphthalimide
• CAS No.: 5022-29-7
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.187
• Hs Code.: 29251995
• European Community (EC) Number: 225-707-3
• NSC Number: 2774
• UNII: 2PU4A53CO7
• DSSTox Substance ID: DTXSID4052134
• Nikkaji Number: J50.516A
• Wikidata: Q72476803
• Mol file: 5022-29-7.mol

Synonyms:N-Ethylphthalimide;5022-29-7;2-ethylisoindoline-1,3-dione;PHTHALIMIDE, N-ETHYL-;2-ethylisoindole-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-ethyl-;1H-Isoindole-1,3(2H)-dione, N-ethyl-;2-Ethyl-1H-isoindole-1,3(2H)-dione;NSC 2774;EINECS 225-707-3;BRN 0132094;AI3-01394;2PU4A53CO7;NSC-2774;1H-Iosindole-1,3(2H)-dione, 2-ethyl-;2-ethyl-2,3-dihydro-1H-isoindole-1,3-dione;5-21-10-00274 (Beilstein Handbook Reference);NSC2774;MFCD00014583;N-Ethylphthalimide, 98%;UNII-2PU4A53CO7;SCHEMBL92102;1H-Isoindole-1, N-ethyl-;WLN: T56 BVNVJ C2;DTXSID4052134;ethyl-1H-isoindole-1,3(2H)-dione;AKOS003239984;AS-59617;2-Ethyl-1H-isoindole-1,3(2H)-dione #;LS-109470;CS-0323043;FT-0676424;F83667;AG-455/02685023;W-110005

Chemical Property of N-Ethylphthalimide

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.00279mmHg at 25°C
• Melting Point: 73-77 °C
• Refractive Index: 1.584
• Boiling Point: 285.5 °C at 760 mmHg
• PKA: -2.09±0.20(Predicted)
• Flash Point: 121.8 °C
• PSA: 37.38000
• Density: 1.249 g/cm³
• LogP: 1.24040
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 175.063328530
• Heavy Atom Count: 13
• Complexity: 225

Purity/Quality:

98% , ^*data from raw suppliers

N-Ethylphthalimide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36

MSDS Files:

Useful:

• Canonical SMILES: CCN1C(=O)C2=CC=CC=C2C1=O

Technology Process of N-Ethylphthalimide

There total 68 articles about N-Ethylphthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N,N'-diethylphthalic diamide (22011-24-1) → N-ethylphthalimide (5022-29-7)

Guidance literature:

With hydrogenchloride; at 20 ℃; under 750.06 Torr;

DOI:10.1016/S0040-4020(00)00511-1

Reference yield: 100.0%

N-vinylphthalimide (3485-84-5,26809-43-8) → N-ethylphthalimide (5022-29-7)

Guidance literature:

With hydrogen; C₃₉H₃₂I₂OP₂Pd; at 20 ℃; for 0.25h;

DOI:10.1021/jacs.0c09254

Reference yield: 100.0%

ethyl bromide (74-96-4) + potassium phtalimide (1074-82-4) → N-ethylphthalimide (5022-29-7)

Guidance literature:

[2.2.2]cryptande; In tetrahydrofuran; for 0.00833333h;

DOI:10.1016/0040-4020(80)87022-0

upstream raw materials:

phthalic anhydride

N-Ethylurea

ethylamine

phthalimide

Downstream raw materials:

2-ethyl-3-benzyl-3-hydroxy-isoindolin-1-one

N,N'-diethylphthalic diamide

4-amino-N-ethylphthalimide

N¹,N²-dimethylphthalamide

Refernces

• 1、 -. "Preparation method of N - alkyl -4 -nitrophthalimide". Paragraph 0043-0044. . Retrieved 2021/10/27.
• 2、 Kumar, Palanichamy Santhosh,Kumar, Kuruba Bharath,Obadiah, Asir,Kumar, Suluvoy Jagadish,Mohanapriya, Raman,Durairaj, Arulappan,Ramanathan, Subramanian,Vasanthkumar, Samuel. "Synthesis, molecular docking, cytotoxicity and antioxidant activity evaluation of isoindoline-1,3-dione derivatives". . p. 2548 - 2556. Retrieved 2019/10/02.