2,3-Dimethylquinoline

Base Information

• Chemical Name: 2,3-Dimethylquinoline
• CAS No.: 1721-89-7
• Molecular Formula: C11H11 N
• Molecular Weight: 157.215
• European Community (EC) Number: 217-016-0
• DSSTox Substance ID: DTXSID00169207
• Nikkaji Number: J28.301K
• Wikidata: Q69754406
• Mol file: 1721-89-7.mol

Synonyms:2,3-DIMETHYLQUINOLINE;1721-89-7;Quinoline, 2,3-dimethyl-;EINECS 217-016-0;SCHEMBL422035;DTXSID00169207;BAA72189;MFCD03085977;AKOS005079387;SB68504;CS-0258436;FT-0702018;EN300-701405;AO-801/41077381;11T-0826

Chemical Property of 2,3-Dimethylquinoline

Chemical Property:

• Vapor Pressure: 0.0134mmHg at 25°C
• Melting Point: 70°C
• Refractive Index: 1.6110 (estimate)
• Boiling Point: 267.4°Cat760mmHg
• PKA: pK1:4.94(+1) (25°C)
• Flash Point: 109.7°C
• PSA: 12.89000
• Density: 1.052g/cm³
• LogP: 2.85160
• Storage Temp.: 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 157.089149355
• Heavy Atom Count: 12
• Complexity: 155

Purity/Quality:

98%Min ^*data from raw suppliers

2,3-Dimethylquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=CC=CC=C2N=C1C

Technology Process of 2,3-Dimethylquinoline

There total 60 articles about 2,3-Dimethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(E)-4-(2-aminophenyl)-3-methylbut-3-en-2-one (698379-40-7) → 2,3-dimethylquinoline (1721-89-7)

Guidance literature:

In tetrahydrofuran; for 72h; Irradiation;

DOI:10.1039/c7ob00558j

Reference yield: 86.0%

1-(2-aminophenyl)-2-methylbut-3-en-1-ol (501700-22-7) → 2,3-dimethylquinoline (1721-89-7)

Guidance literature:

With 1,10-Phenanthroline; air; palladium diacetate; In methanol; at 25 ℃; for 36h; under 760.051 Torr;

DOI:10.1021/ol702153x

Reference yield: 81.0%

C12H14N2O5 (1253423-87-8) → 2,3-dimethylquinoline (1721-89-7)

Guidance literature:

With iron; In acetic acid; for 2h; Reflux;

DOI:10.1016/j.tetlet.2010.07.063

upstream raw materials:

acridine

4-chloro-2,3-dimethylquinoline

2,3-dimethyl-quinoline-8-carboxylic acid

2-methyl-2-pentenal

Downstream raw materials:

2-(3-methylquinolyliden-2-yl)-1-phenylethanone

2,4,6-Trimethyl-benzenesulfonate1-amino-2,3-dimethyl-quinolinium;

glyoxime

butane-2,3-dione dioxime

Refernces

• 1、 Rohde. "-". . p. 269. Retrieved 1889.
• 2、 Poth et al.. "-". . p. 1239,1249. Retrieved 1930.
• 3、 Gao, Zhuyan,Huang, Zhipeng,Lu, Jianmin,Mu, Junju,Ren, Puning,Su, Kaiyi,Wang, Feng,Zhang, Chaofeng,Zhang, Shichao. "Oxygen-implanted MoS2 nanosheets promoting quinoline synthesis from nitroarenes and aliphatic alcohols via an integrated oxidation transfer hydrogenation-cyclization mechanism". . p. 1704 - 1713. Retrieved 2022/03/08.
• 4、 Gao, Yang,Nie, Jianhong,Li, Yibiao,Li, Xianwei,Chen, Qian,Huo, Yanping,Hu, Xiao-Qiang. "Rh-Catalyzed C-H Amination/Annulation of Acrylic Acids and Anthranils by Using -COOH as a Deciduous Directing Group: An Access to Diverse Quinolines". supporting information. p. 2600 - 2605. Retrieved 2020/04/02.