diisopropyl benzylphosphoramidate

Base Information

• Chemical Name: diisopropyl benzylphosphoramidate
• CAS No.: 59658-74-1
• Molecular Formula: C₁₃H₂₂NO₃P
• Molecular Weight: 271.296
• Mol file: 59658-74-1.mol

Synonyms:diisopropyl benzylphosphoramidate

Chemical Property of diisopropyl benzylphosphoramidate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of diisopropyl benzylphosphoramidate

There total 5 articles about diisopropyl benzylphosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

diisopropyl phosphite (691-96-3) + N-(phenylmethyl)-2-benzothiazolesulfenamide (26773-69-3) → diisopropyl benzylphosphoramidate (59658-74-1) + 2-Mercaptobenzothiazole (149-30-4,118090-09-8)

Guidance literature:

DOI:10.1246/cl.1980.695

Reference yield: 75.0%

diisopropyl phosphoryl azide (7108-90-9) + benzylamine (100-46-9) → diisopropyl benzylphosphoramidate (59658-74-1)

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; for 12h; Schlenk technique; Green chemistry;

DOI:10.1039/c9ra03389k

Reference yield: 68.0%

diisopropyl hydrogenphosphonate (1809-20-7) + benzylamine (100-46-9) → diisopropyl benzylphosphoramidate (59658-74-1)

Guidance literature:

diisopropyl hydrogenphosphonate; With trichloroisocyanuric acid; In acetonitrile; at 20 ℃; for 0.25h;

benzylamine; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1055/s-0036-1589111

upstream raw materials:

Diisopropyl chlorophosphate

benzylamine

diisopropyl hydrogenphosphonate

diisopropyl phosphite

Refernces

• 1、 Li, Qing,Sun, Xiaohua,Yang, Xiaoqin,Wu, Minghu,Sun, Shaofa,Chen, Xiuling. "Transition-metal-free amination phosphoryl azide for the synthesis of phosphoramidates". . p. 16040 - 16043. Retrieved 2019/06/10.
• 2、 Kaboudin, Babak,Kazemi, Foad,Habibi, Fereshteh. "Fe3O4@MgO nanoparticles as an efficient recyclable catalyst for the synthesis of phosphoroamidates via the Atherton-Todd reaction Dedicated to Professor Tsutomu Yokomatsu from Tokyo University of Pharmacy and Life Sciences on the occasion of his 65th birthday". supporting information. p. 6364 - 6367. Retrieved 2015/11/16.