Technology Process of 3-phenylpropionic acid (2S)-2-(methyloxiranyl)ethyl ester
There total 5 articles about 3-phenylpropionic acid (2S)-2-(methyloxiranyl)ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-phenylpropionic acid (3S)-3,4-dihydroxy-3-methylbutyl ester;
With
methanesulfonyl chloride; triethylamine;
In
dichloromethane;
at -10 ℃;
for 0.333333h;
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
dichloromethane;
at 20 ℃;
for 4h;
Further stages.;
DOI:10.1021/jo005665y
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: H2SO4; MeOH
1.2: 72 percent / LAH / tetrahydrofuran
2.1: 81 percent / P2O5 / 15 h / 20 °C
3.1: 79 percent / DMAP; EDCI / CH2Cl2 / 15 h / 20 °C
4.1: 57 percent / pTsOH / tetrahydrofuran; H2O / 4 h / Heating
5.1: MsCl; Et3N / CH2Cl2 / 0.33 h / -10 °C
5.2: 82 percent / DBU / CH2Cl2 / 4 h / 20 °C
With
methanol; dmap; sulfuric acid; phosphorus pentoxide; toluene-4-sulfonic acid; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo005665y
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 81 percent / P2O5 / 15 h / 20 °C
2.1: 79 percent / DMAP; EDCI / CH2Cl2 / 15 h / 20 °C
3.1: 57 percent / pTsOH / tetrahydrofuran; H2O / 4 h / Heating
4.1: MsCl; Et3N / CH2Cl2 / 0.33 h / -10 °C
4.2: 82 percent / DBU / CH2Cl2 / 4 h / 20 °C
With
dmap; phosphorus pentoxide; toluene-4-sulfonic acid; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo005665y
