Bemegride

Base Information

• Chemical Name: Bemegride
• CAS No.: 64-65-3
• Molecular Formula: C8H13 N O2
• Molecular Weight: 155.197
• Hs Code.: 2925190090
• European Community (EC) Number: 200-588-0
• NSC Number: 58187
• UN Number: 2811
• UNII: 57DQA39DO2
• DSSTox Substance ID: DTXSID0045250
• Nikkaji Number: J1.404D
• Wikipedia: Bemegride
• Wikidata: Q792614
• NCI Thesaurus Code: C76617
• Metabolomics Workbench ID: 154523
• ChEMBL ID: CHEMBL1214192
• Mol file: 64-65-3.mol

Synonyms:Bemegride;Ethylmethylglutarimide;Megimide;Methetharimide

Chemical Property of Bemegride

Chemical Property:

• Appearance/Colour: white to off-white flakes or powder
• Vapor Pressure: 0.00344mmHg at 25°C
• Melting Point: 126-127 °C(lit.)
• Refractive Index: 1.4860 (estimate)
• Boiling Point: 282oC at 760 mmHg
• PKA: pKa 11.7 (Uncertain)
• Flash Point: 125.8oC
• PSA: 46.17000
• Density: 1.024g/cm3
• LogP: 1.16810
• Storage Temp.: −20°C
• Water Solubility.: Soluble in water
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 155.094628657
• Heavy Atom Count: 11
• Complexity: 182
• Transport DOT Label: Poison

Purity/Quality:

3-Ethyl-3-methylglutarimide >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 22-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1(CC(=O)NC(=O)C1)C
• Uses: CNS stimulant;GABA antagonist

Technology Process of Bemegride

There total 11 articles about Bemegride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-ethyl-3-methylglutaric anhydride (6970-57-6) → bemegride (64-65-3)

Guidance literature:

With ammonia; at 200 ℃;

Reference yield:

3-ethyl-3-methylglutaric acid (5345-01-7) → bemegride (64-65-3)

Guidance literature:

With ammonia; water; at 200 ℃;

Reference yield:

→ bemegride (64-65-3)

Guidance literature:

With potassium hydroxide;

upstream raw materials:

3-ethyl-3-methylglutaric anhydride

urea

3-ethyl-3-methylglutaric acid

formamide

Downstream raw materials:

4-ethyl-1-[4-(α-hydroxy-benzhydryl)-piperidinomethyl]-4-methyl-piperidine-2,6-dione

4-ethyl-4-methylpiperidine

3-Methyl-3-ethyl-1.5-amylenglykol-bis-p-nitrobenzoat

1-benzyl-4-ethyl-4-methyl-piperidine-2,6-dione

Refernces