alpha-Ketoglutaramate

Base Information

• Chemical Name: alpha-Ketoglutaramate
• CAS No.: 18465-19-5
• Molecular Formula: C5H7 N O4
• Molecular Weight: 145.115
• Hs Code.: 2922509090
• DSSTox Substance ID: DTXSID60171604
• Nikkaji Number: J39.559E
• Wikidata: Q27104163
• Metabolomics Workbench ID: 37866
• Mol file: 18465-19-5.mol

Synonyms:2-oxoglutaramate;alpha-ketoglutaramate

Chemical Property of alpha-Ketoglutaramate

Chemical Property:

• Vapor Pressure: 1.05E-07mmHg at 25°C
• Melting Point: 158-160℃ (isopropanol )
• Boiling Point: 405.4°C at 760 mmHg
• PKA: 2.50±0.54(Predicted)
• Flash Point: 199°C
• PSA: 97.46000
• Density: 1.400±0.06 g/cm3(Predicted)
• LogP: -0.39410
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 145.03750770
• Heavy Atom Count: 10
• Complexity: 175

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(=O)N)C(=O)C(=O)O
• Uses: 2-Oxoglutaramic Acid is an important glutamine metabolite in mammals, plants, and many bacteria.

Technology Process of alpha-Ketoglutaramate

There total 3 articles about alpha-Ketoglutaramate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-glutamine (56-85-9,26700-71-0) → 2-keto-glutaramic acid (18465-19-5)

Guidance literature:

With recombinant Pseudoalteromonas luteoviolacea L-amino acid oxidase; In aq. phosphate buffer; at 37 ℃; for 0.25h; pH=7.4; Enzymatic reaction;

DOI:10.3390/md16120499

Reference yield:

L-glutamine (56-85-9,26700-71-0) + NADP (53-59-8) → 2-keto-glutaramic acid (18465-19-5) + NADPH (53-57-6)

Guidance literature:

With glutamate dehydrogenase; ethylenediaminetetraacetic acid; Pyrococcus horikoshii OT₃ ATP pyrophosphatase; Pyrococcus horikoshii OT₃ glutamine amidotransferase; XMP; ATP; magnesium chloride; pH=8; aq. buffer;

DOI:10.1016/j.jmb.2009.10.053

Reference yield:

L-glutamine (56-85-9,26700-71-0) → α-ketoglutaric acid (328-50-7) + 2-keto-glutaramic acid (18465-19-5)

Guidance literature:

enzymatische Reaktion mit 2-Oxo-carbonsaeuren;

upstream raw materials:

L-glutamine

NADP

Refernces

• 1、 Andreo-Vidal, Andrés,Sanchez-Amat, Antonio,Campillo-Brocal, Jonatan C.. "The pseudoalteromonas luteoviolacea L-amino acid oxidase with antimicrobial activity is a flavoenzyme". . . Retrieved 2019/01/03.