7alpha,14alpha-Dihydroxyprogesterone

Base Information

• Chemical Name: 7alpha,14alpha-Dihydroxyprogesterone
• CAS No.: 640-30-2
• Molecular Formula: C21H30 O4
• Molecular Weight: 346.467
• Nikkaji Number: J658.869G
• Mol file: 640-30-2.mol

Synonyms:7,14-dihydroxypregn-4-ene-3,20-dione;7,14-dihydroxypregn-4-ene-3,20-dione, (7beta,14xi)-isomer;DPED

Chemical Property of 7alpha,14alpha-Dihydroxyprogesterone

Chemical Property:

• Vapor Pressure: 3.65E-13mmHg at 25°C
• Boiling Point: 523.9°C at 760 mmHg
• Flash Point: 284.7°C
• PSA: 74.60000
• Density: 1.21g/cm³
• LogP: 2.80920
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 346.21440943
• Heavy Atom Count: 25
• Complexity: 667

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1CCC2(C1(CCC3C2C(CC4=CC(=O)CCC34C)O)C)O
• Isomeric SMILES: CC(=O)[C@H]1CC[C@@]2([C@@]1(CC[C@H]3[C@H]2[C@@H](CC4=CC(=O)CC[C@]34C)O)C)O

Technology Process of 7alpha,14alpha-Dihydroxyprogesterone

There total 2 articles about 7alpha,14alpha-Dihydroxyprogesterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Progesterone (57-83-0) → 14-hydroxy-4-pregnene-3,20-dione (16031-66-6) + 6β,24α-dihydroxypregn-4-ene-3,20-dione (599-27-9) + 7α,14α-dihydroxypregn-4-ene-3,20-dione (640-30-2)

Guidance literature:

With sodium nitrate; dipotassium hydrogenphosphate; potassium dihydrogenphosphate; D-glucose; cornsteep liquor; potassium chloride; magnesium sulfate; iron(II) sulfate; In acetone; at 27 ℃; Mucor griseocyanus ATCC 1207A;

DOI:10.1016/0039-128X(95)00006-C

Reference yield:

Progesterone (57-83-0) → 14-hydroxy-4-pregnene-3,20-dione (16031-66-6) + 9α-hydroxypregn-4-ene-3,20-dione (15981-54-1) + 7α,14α-dihydroxypregn-4-ene-3,20-dione (640-30-2)

Guidance literature:

With sodium nitrate; dipotassium hydrogenphosphate; potassium dihydrogenphosphate; D-glucose; cornsteep liquor; Thamnostylum piriforme ATCC 8992; potassium chloride; magnesium sulfate; iron(II) sulfate; In acetone; at 27 ℃; for 24h; Product distribution; Kinetics; var. of microorganism, time, other steroids;

DOI:10.1016/0039-128X(95)00006-C

upstream raw materials:

Progesterone

Refernces