2-Thiophenemethylamine

Base Information

• Chemical Name: 2-Thiophenemethylamine
• CAS No.: 27757-85-3
• Molecular Formula: C5H7NS
• Molecular Weight: 113.183
• Hs Code.: 29349990
• European Community (EC) Number: 231-011-0,248-639-6
• DSSTox Substance ID: DTXSID7075343
• Nikkaji Number: J88.516I
• Wikidata: Q72508868
• ChEMBL ID: CHEMBL237711
• Mol file: 27757-85-3.mol

Synonyms:2-Thiophenemethylamine;27757-85-3;thiophen-2-ylmethanamine;2-Thienylmethylamine;Thiophenemethanamine;Thiophene-2-methylamine;2-(Aminomethyl)thiophene;2-THIOPHENEMETHANAMINE;2-Aminomethylthiophene;2-Thenylamine;(2-Thienylmethyl)amine;1-(thiophen-2-yl)methanamine;(2-thienyl)methylamine;2-thiophene methylamine;thiophene-2-methanamine;MFCD00005460;(thiophen-2-yl)methanamine;CHEMBL237711;EINECS 248-639-6;7404-63-9;2-Thienylmethanamine;55230-88-1;thenylamine;thienylmethylamine;Thiophenemethylamine;2-thienylmethyl amine;5-aminomethylthiophene;thiophene methyl amine;2-thiophenylmethylamine;thiophene methane amine;2-aminomethyl thiophene;2-aminomethyl-thiophene;5-aminomethyl-thiophene;2-Thienylmethanamine #;2-Thiophene-methylamine;2-thiopheneylmethanamine;thiophen-2-ylmethylamine;2-thiophene methyl amine;thiophene-2-ylmethanamine;thiophen-2-yl-methanamine;thiophen-2-ylmethyl-amine;1-(2-thienyl)methanamine;1-(2-thienyl)methylamine;2-(aminomethyl)-thiophene;1-thiophen-2-ylmethanamine;thiophen-2-yl-methyl-amine;2-(2-Aminomethyl)thiophene;(thiophen-2-yl-methyl)amine;SCHEMBL121154;DTXSID7075343;(2-Thienylmethyl)ammonium chloride;C-THIOPHEN-2-YL-METHYLAMINE;EINECS 231-011-0;BDBM50227501;STL185547;AKOS000120646;CS-W007649;NSC 400116;PB17027;PS-5819;AC-15711;AM803624;4-OH-7-3FmEt-3-quinolinecarboxylic acid;BB 0218285;FT-0608728;EN300-20989;A819180;J-640139;J-800143;W-107096;F2169-1040;Z104485908

Chemical Property of 2-Thiophenemethylamine

Chemical Property:

• Appearance/Colour: clear yellow liquid
• Refractive Index: n20/D 1.5670(lit.)
• Boiling Point: 194.509 °C at 760 mmHg
• PKA: 8.95±0.29(Predicted)
• Flash Point: 73.889 °C
• PSA: 54.26000
• Density: 1.144 g/cm³
• LogP: 1.90710
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Air Sensitive
• Solubility.: Easily soluble in ethanol and Chloroform.
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 113.02992040
• Heavy Atom Count: 7
• Complexity: 56

Purity/Quality:

95%, 99% ^*data from raw suppliers

2-Thiophenemethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45-25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)CN
• Uses: 2-Thiophenemethylamine can be used as areactant involved in synthesis of Triazole-linked-thiopene conjugates and a biomimetic model for studies of metal detoxification and oxidative stress involving metallothionein. 2-Thiophenemethylamine is Reactant involved in synthesis of: Triazole-linked-thiopene conjugates. It is used for biomimetic model for studies of metal detoxification and oxidative stress involving metallothionein.It is a reactant involved in studies of organocatalyzed asymmetric reductive amination of ketones. Reactant involved in synthesis of:Triazole-linked-thiopene conjugates for use as a biomimetic model for studies of metal detoxification and oxidative stress involving metallothioneinSerotonin 5-HT1A receptor antagonists which have neuroprotective affects against ischemic cell damageImidazole- and piperonyl-containing thiadiazoles and pyrimidines for use as inducible oxide synthase dimerization inhibitorsOptoelectronic segmented polyurethanesReactant involved in:Studies of organocatalyzed asymmetric reductive amination of ketonesMetal-free aerobic oxidative coupling of amines to imines

Technology Process of 2-Thiophenemethylamine

There total 43 articles about 2-Thiophenemethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

thiophene-2-carbonitrile (1003-31-2) → 2-Aminomethylthiophene (27757-85-3)

Guidance literature:

With [Ru(H)(BH₄)(CO)(PPh₃)(3-(di-tert-butylphosphino)-N-((1-methyl-1H-imidazol-2 yl)methyl)propylamine)]; hydrogen; In isopropyl alcohol; at 70 ℃; for 3h; Inert atmosphere; Autoclave;

DOI:10.1002/chem.201504709

Reference yield: 81.5%

tert-butyl N-(thiophen-2-ylmethyl)carbamate (401485-19-6) → 2-Aminomethylthiophene (27757-85-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.2174/1570180815666180803125935

Reference yield: 73.0%

thiophene-2-methylamine methyl carbamate → 2-Aminomethylthiophene (27757-85-3) + methanol (67-56-1)

Guidance literature:

With C₃₀H₂₉BrMnNO₂P₂; potassium tert-butylate; In isopropyl alcohol; toluene; at 120 ℃; for 16h;

DOI:10.1039/d1sc02663a

upstream raw materials:

thiophene

formaldehyd

2-Chloromethylthiophene

hexamethylenetetramine

Downstream raw materials:

2-(pyridin-2-yl)-N-(thiophen-2-ylmethyl)ethanamine

2-<(N-succinoylamino)methyl>thiophene

N-(thien-2-ylmethyl)phthalimide

[2-(2-methoxy-phenyl)-1-methyl-ethyl]-[2]thienylmethyl-amine

Refernces

• 1、 Bhanage, Bhalchandra M.,Gokhale, Tejas A.,Raut, Amol B.. "Comparative account of catalytic activity of Ru- and Ni-based nanocomposites towards reductive amination of biomass derived molecules". . . Retrieved 2021/06/18.
• 2、 Liu, Xin,Werner, Thomas. "Indirect reduction of CO2and recycling of polymers by manganese-catalyzed transfer hydrogenation of amides, carbamates, urea derivatives, and polyurethanes". . p. 10590 - 10597. Retrieved 2021/08/20.