2,5-Diphenylfuran

Base Information

• Chemical Name: 2,5-Diphenylfuran
• CAS No.: 955-83-9
• Deprecated CAS: 60605-33-6
• Molecular Formula: C16H12 O
• Molecular Weight: 220.271
• Hs Code.: 29321900
• European Community (EC) Number: 213-474-0
• NSC Number: 97358
• UNII: 2FGD8BE3PZ
• DSSTox Substance ID: DTXSID5022142
• Nikkaji Number: J102.719K
• Wikidata: Q27122078
• Metabolomics Workbench ID: 57432
• ChEMBL ID: CHEMBL109224
• Mol file: 955-83-9.mol

Synonyms:2,5-diphenylfuran

Chemical Property of 2,5-Diphenylfuran

Chemical Property:

• Appearance/Colour: yellow-beige powder and chunks
• Vapor Pressure: 0.000135mmHg at 25°C
• Melting Point: 86-90 °C
• Refractive Index: 1.5800 (estimate)
• Boiling Point: 345 °C
• Flash Point: 164.3°C
• PSA: 13.14000
• Density: 1.086g/cm³
• LogP: 4.61360
• Solubility.: soluble in Methanol
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 220.088815002
• Heavy Atom Count: 17
• Complexity: 202

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-Diphenylfuran ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=C(O2)C3=CC=CC=C3
• Recent ClinicalTrials: Clinical and Radiographic Evaluation of PPF With or Without NCHA Bone in Treatment of Intrabony Defects

Technology Process of 2,5-Diphenylfuran

There total 144 articles about 2,5-Diphenylfuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phenacylacetophenone (495-71-6) → 2,5-diphenylfuran (955-83-9)

Guidance literature:

With 1-butyl-3-methylimidazolium hydrogen sulfate; at 150 ℃; for 2h; Sealed tube; Neat (no solvent);

DOI:10.1080/00397910902978049

Reference yield: 99.0%

1,4-diphenyl-1,3-butadiyne (886-66-8) → 2,5-diphenylfuran (955-83-9)

Guidance literature:

With water; potassium hydroxide; In dimethyl sulfoxide; at 80 ℃; for 24h;

DOI:10.1055/s-0032-1316872

Reference yield: 96.0%

1,4-diphenylbut-2-ene-1,4-dione (959-28-4) → 2,5-diphenylfuran (955-83-9)

Guidance literature:

With formic acid; palladium on activated charcoal; In various solvent(s); for 0.0166667h; microwave irradiation;

DOI:10.1021/jo0341766

upstream raw materials:

4-bromo-3-nitro-1,4-diphenyl-butan-1-one

1,4-diphenylbut-2-ene-1,4-dione

phenacylacetophenone

5-ethoxy-2,5-dihydrofuran-2-one

Downstream raw materials:

C₄₀H₃₀O₄

C₄₀H₃₀O₂

p-nitrobenzanilide

(Z)-2-(4-nitrophenylamino)-1,4-diphenylbut-2-ene-1,4-dione

Refernces

• 1、 Schirmacher, Robert H.E.,R?sch, Daniel,Thomas, Franziska. "Hexafluoroisopropanol as solvent and promotor in the Paal-Knorr synthesis of N-substituted diaryl pyrroles". . . Retrieved 2021/02/20.
• 2、 -. "Method for preparing furan compound from brominated arone". Page/Page column 5. . Retrieved 2021/06/13.