5-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pent-4-ynoic acid (furan-2-ylmethyl)-amide

Base Information

• Chemical Name: 5-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pent-4-ynoic acid (furan-2-ylmethyl)-amide
• CAS No.: 473260-09-2
• Molecular Formula: C₄₀H₃₉N₃O₉
• Molecular Weight: 705.764
• Mol file: 473260-09-2.mol

Synonyms:5-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pent-4-ynoic acid (furan-2-ylmethyl)-amide

Chemical Property of 5-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pent-4-ynoic acid (furan-2-ylmethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pent-4-ynoic acid (furan-2-ylmethyl)-amide

There total 5 articles about 5-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pent-4-ynoic acid (furan-2-ylmethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine (104375-88-4) + N-(furan-2-ylmethyl)pent-4-ynamide (473260-07-0) → 5-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pent-4-ynoic acid (furan-2-ylmethyl)-amide (473260-09-2)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(02)00930-9

Reference yield:

furan-2-ylmethanamine (617-89-0) → 5-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pent-4-ynoic acid (furan-2-ylmethyl)-amide (473260-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / carbonyl diimidazole / dimethylformamide / 40 °C

2: 79 percent / triethylamine; CuI; Pd(PPh₃)4 / dimethylformamide

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(02)00930-9

Reference yield:

4-pentynoic acid (6089-09-4) → 5-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pent-4-ynoic acid (furan-2-ylmethyl)-amide (473260-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / carbonyl diimidazole / dimethylformamide / 40 °C

2: 79 percent / triethylamine; CuI; Pd(PPh₃)4 / dimethylformamide

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(02)00930-9

upstream raw materials:

2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine

N-(furan-2-ylmethyl)pent-4-ynamide

furan-2-ylmethanamine

4-pentynoic acid

Refernces