C₁₀H₈F₅N

Base Information

• Chemical Name: C₁₀H₈F₅N
• CAS No.: 1292820-93-9
• Molecular Formula: C₁₀H₈F₅N
• Molecular Weight: 237.172
• Mol file: 1292820-93-9.mol

Synonyms:C₁₀H₈F₅N

Chemical Property of C₁₀H₈F₅N

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₀H₈F₅N

There total 1 articles about C₁₀H₈F₅N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethoxy-2,2,3,3,3-pentafluoro-propan-1-ol (337-28-0) + benzylamine (100-46-9) → C10H8F5N (1292820-93-9)

Guidance literature:

In toluene; Reflux;

DOI:10.1002/adsc.201000843

Reference yield: 99.0%

(furan-2-yloxy)-trimethylsilane (61550-02-5) + C10H8F5N (1292820-93-9) → C14H12F5NO2

Guidance literature:

(furan-2-yloxy)-trimethylsilane; C₁₀H₈F₅N; With ethanol; silver(I) acetate; triphenylphosphine; In tetrahydrofuran; at -78 ℃; for 7h; Molecular sieve;

With acetic acid; In tetrahydrofuran; methanol; at -78 ℃; for 2h;

DOI:10.1002/adsc.201000843

Reference yield: 89.0%

1,3-DIOXOLANE (646-06-0) + C10H8F5N (1292820-93-9) → N-benzyl-1-(1,3-dioxolan-2-yl)-2,2,3,3,3-pentafluoropropan-1-amine

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; dimethylglyoxal; at 20 ℃; Molecular sieve; Irradiation; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00128

upstream raw materials:

1-ethoxy-2,2,3,3,3-pentafluoro-propan-1-ol

benzylamine

Refernces

• 1、 Zhao, Qian-Yi,Yuan, Zhi-Liang,Shia, Min. "Highly diastereo- and enantioselective vinylogous Mannich reactions of fluorinated aldimines with siloxyfurans". supporting information; experimental part. p. 637 - 643. Retrieved 2011/04/25.