Pirodomast

Base Information

• Chemical Name: Pirodomast
• CAS No.: 108310-20-9
• Molecular Formula: C18H17 N3 O2
• Molecular Weight: 0
• Mol file: 108310-20-9.mol

Synonyms:Pirodomast;Sch 37224

Chemical Property of Pirodomast

Chemical Property:

• Vapor Pressure: 6.07E-09mmHg at 25°C
• Boiling Point: 451.6°Cat760mmHg
• Flash Point: 226.9°C
• PSA: 58.36000
• Density: 1.391g/cm³
• LogP: 2.75650

Purity/Quality:

97% ^*data from raw suppliers

PIRODOMAST 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pirodomast

There total 3 articles about Pirodomast which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 2-(<(1-pyrrolidinyl)acetyl>phenylamino)-3-pyridinecarboxylate (121558-30-3) → 1,2-dihydro-1-phenyl-3-pyrrolidino-2-oxo-1,8-naphthyridin-4-olate (108310-20-9)

Guidance literature:

With potassium tert-butylate; In various solvent(s); at 0 ℃; for 1h;

DOI:10.1055/s-1991-26519

Reference yield:

methyl 2-phenylamino-nicotinate (51269-84-2) → 1,2-dihydro-1-phenyl-3-pyrrolidino-2-oxo-1,8-naphthyridin-4-olate (108310-20-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / 1,2-epoxybutane / various solvent(s) / 1.5 h / 50 °C

2: 95 percent / various solvent(s); CH₂Cl₂ / 18 h / Heating

3: 82 percent / t-BuOK / various solvent(s) / 1 h / 0 °C

With ethyloxirane; potassium tert-butylate; In dichloromethane;

DOI:10.1055/s-1991-26519

Reference yield:

methyl 2-<(chloroacetyl)phenylamino>-3-pyridinecarboxylate (121558-29-0) → 1,2-dihydro-1-phenyl-3-pyrrolidino-2-oxo-1,8-naphthyridin-4-olate (108310-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / various solvent(s); CH₂Cl₂ / 18 h / Heating

2: 82 percent / t-BuOK / various solvent(s) / 1 h / 0 °C

With potassium tert-butylate; In dichloromethane;

DOI:10.1055/s-1991-26519

upstream raw materials:

methyl 2-(<(1-pyrrolidinyl)acetyl>phenylamino)-3-pyridinecarboxylate

methyl 2-phenylamino-nicotinate

methyl 2-<(chloroacetyl)phenylamino>-3-pyridinecarboxylate

Refernces