(S)-atenolol O-acetyl ester

Base Information

• Chemical Name: (S)-atenolol O-acetyl ester
• CAS No.: 301540-95-4
• Molecular Formula: C₁₆H₂₄N₂O₄
• Molecular Weight: 308.378
• Mol file: 301540-95-4.mol

Synonyms:(S)-atenolol O-acetyl ester

Chemical Property of (S)-atenolol O-acetyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-atenolol O-acetyl ester

There total 6 articles about (S)-atenolol O-acetyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + (RS)-atenolol (29122-68-7) → (+)-(R)-atenolol (56715-13-0) + (S)-Atenolol (93379-54-5) + (S)-atenolol O-acetyl ester (301540-95-4) + (R)-atenolol O-acetyl ester

Guidance literature:

With pseudomonas fluorescens lipase; In tetrahydrofuran; at 45 ℃; Reagent/catalyst; Temperature; Solvent; Resolution of racemate; Enzymatic reaction;

DOI:10.1002/chir.22702

Reference yield:

acetic anhydride (108-24-7) + (S)-Atenolol (93379-54-5) → (S)-atenolol O-acetyl ester (301540-95-4)

Guidance literature:

In acetone; at 59.84 - 64.84 ℃; for 3h;

DOI:10.1002/chir.22769

Reference yield:

(+/-)-atenolol O-acetyl ester → (S)-atenolol O-acetyl ester (301540-95-4) + (R)-atenolol O-acetyl ester

Guidance literature:

With diethylamine; In ethanol; hexane; at 35 ℃; Resolution of racemate;

DOI:10.1002/chir.22769

upstream raw materials:

vinyl acetate

(RS)-atenolol

acetic anhydride

(S)-Atenolol

Downstream raw materials:

(S)-Atenolol

Refernces

• 1、 Agustian, Joni,Kamaruddin, Azlina Harun,Aboul-Enein, Hassan Y.. "Fast liquid chromatography for racemic atenolol acetate separation—The analytical protocol". . p. 847 - 853. Retrieved 2017.
• 2、 Agustian, Joni,Kamaruddin, Azlina Harun,Aboul-Enein, Hassan Y.. "Factors screening to statistical experimental design of racemic atenolol kinetic resolution via transesterification reaction in organic solvent using free Pseudomonas fluorescens lipase". . p. 376 - 385. Retrieved 2017.