2,2-DIPHENYLACETAMIDE

Base Information

• Chemical Name: 2,2-DIPHENYLACETAMIDE
• CAS No.: 4695-13-0
• Molecular Formula: C14H13 N O
• Molecular Weight: 211.263
• Hs Code.: 2924299090
• European Community (EC) Number: 636-924-1
• NSC Number: 29731
• UNII: YZX41252DL
• DSSTox Substance ID: DTXSID80196995
• Nikkaji Number: J8.762I
• Wikidata: Q27294808
• Mol file: 4695-13-0.mol

Synonyms:Acetamide,2,2-diphenyl- (6CI,7CI,8CI); 2,2-Diphenylacetamide; Diphenylacetic acid amide;NSC 29731; a,a-Diphenylacetamide

Chemical Property of 2,2-DIPHENYLACETAMIDE

Chemical Property:

• Vapor Pressure: 2.55E-06mmHg at 25°C
• Melting Point: 164-167°C
• Boiling Point: 391°Cat760mmHg
• Flash Point: 190.3°C
• PSA: 43.09000
• Density: 1.13g/cm³
• LogP: 3.00410
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 211.099714038
• Heavy Atom Count: 16
• Complexity: 209

Purity/Quality:

99%, ^*data from raw suppliers

2,2-Diphenylacetamide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R22:Harmful if swallowed.
• Hazard Codes: R22:Harmful if swallowed.
• Statements: 22
• Safety Statements: 22-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)N

Technology Process of 2,2-DIPHENYLACETAMIDE

There total 64 articles about 2,2-DIPHENYLACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Diphenylacetonitrile (86-29-3) → 2,2-diphenylacetamide (4695-13-0)

Guidance literature:

With sodium hydroxide; poly(ethylene glycol)-400; for 0.025h; microwave irradiation;

DOI:10.1080/00397910008087213

Reference yield: 90.0%

1-(1H-benzo[d][1,2,3]triazol-1-yl)-2,2-diphenylethan-1-one (182318-00-9) → 2,2-diphenylacetamide (4695-13-0)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 4h;

DOI:10.1021/jo000792f

Reference yield: 85.0%

C19H21N3O (1309976-99-5) → 2,2-diphenylacetamide (4695-13-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

DOI:10.1016/j.tetlet.2011.04.042

upstream raw materials:

1,1-Diphenylethylene

diphenylacetic acid chloride

ethanol

2,2-diphenyl-acetimidic acid ethyl ester; hydrochloride

Downstream raw materials:

2-diphenylmethyleneoxazolidine-4,5-dione

1,1-diphenylbutan-2-one

Benzhydryl-carbamidsaeure-ethylester

1,2,2-triphenylethan-1-one

Refernces

• 1、 Reid,Hunter. "-". . p. 3515. Retrieved 1948.
• 2、 Arashiba, Kazuya,Itabashi, Takayuki,Kuriyama, Shogo,Nishibayashi, Yoshiaki. "Reactivity of molybdenum-nitride complex bearing pyridine-based PNP-type pincer ligand toward carbon-centered electrophiles". . p. 1946 - 1954. Retrieved 2022/02/11.
• 3、 Babón, Juan C.,Esteruelas, Miguel A.,López, Ana M.,O?ate, Enrique. "Hydration of Aliphatic Nitriles Catalyzed by an Osmium Polyhydride: Evidence for an Alternative Mechanism". . p. 7284 - 7296. Retrieved 2021/05/29.