Proglumide

Base Information Edit

Chemical Name:Proglumide
CAS No.:6620-60-6
Deprecated CAS:24485-90-3,25727-74-6
Molecular Formula:C18H26N2O4
Molecular Weight:334.415
Hs Code.:2924299090
European Community (EC) Number:229-567-4
NSC Number:757841
UNII:EPL8W5565D
DSSTox Substance ID:DTXSID7023516
Nikkaji Number:J3.421E
Wikipedia:Proglumide
Wikidata:Q7248362
NCI Thesaurus Code:C81916
Pharos Ligand ID:2SL7FVBYKVCA
Metabolomics Workbench ID:143620
ChEMBL ID:CHEMBL316561
Mol file:6620-60-6.mol

Synonyms:Milid;Proglumide;Xilamide;Xylamide

Suppliers and Price of Proglumide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Proglumide
2g
$ 155.00

Medical Isotopes, Inc.
Proglumide
5 g
$ 650.00

CSNpharm
Proglumide
1g
$ 450.00

CSNpharm
Proglumide
250mg
$ 150.00

Crysdot
4-Benzamido-5-(dipropylamino)-5-oxopentanoicacid 97%
100mg
$ 150.00

ChemScene
Proglumide 99.74%
100mg
$ 110.00

ChemScene
Proglumide 99.74%
50mg
$ 60.00

Chemenu
4-Benzamido-5-(dipropylamino)-5-oxopentanoicacid 97%
1g
$ 421.00

Biosynth Carbosynth
Proglumide
100 mg
$ 50.00

AvaChem
Proglumide
1g
$ 89.00

Total 130 raw suppliers

Chemical Property of Proglumide Edit

Chemical Property:

Appearance/Colour:White solid
Vapor Pressure:9.33E-15mmHg at 25°C
Melting Point:148-150°C
Refractive Index:1.534
Boiling Point:589.8 °C at 760 mmHg
PKA:4.51±0.10(Predicted)
Flash Point:310.5 °C
PSA：86.71000
Density:1.136 g/cm³
LogP:2.68930
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:10
Exact Mass:334.18925731
Heavy Atom Count:24
Complexity:413

Purity/Quality:

99%, ^*data from raw suppliers

Proglumide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)C1=CC=CC=C1
Recent ClinicalTrials:Role of a CCK Receptor Antagonist Proglumide in Management of Chronic Pancreatitis
Recent EU Clinical Trials:A pivotal, multicentre, randomized, modified double-blind, placebo-controlled phase 3 trial to assess the safety and clinical efficacy of M-001, an influenza vaccine administered intramuscularly twice in older adults and the elderly (≥50 years of age).
Description Proglumide (Milid) is a drug that inhibits gastrointestinal motility and reduces gastric secretions. It acts as a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. It was used mainly in the treatment of stomach ulcers, although it has now been largely replaced by newer drugs for this application.Proglumide is a nonpeptide and orally active cholecystokinin (CCK)-A/B receptors antagonist. Proglumide selective blocks CCK’s effects in the central nervous system (CNS). Proglumide has ability to inhibit gastric secretion and to protect the gastroduodenal mucosa. Proglumide also has antiepileptic and antioxidant activities.
Uses Anticholinergic.

Technology Process of Proglumide

There total 11 articles about Proglumide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%